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STUDIES ON ADSORPTION TIAMFENICOL ON CHITOSANS DEGRADED RADIATION IN PHARMACEUTICAL IN VITRO MODEL

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Meler J., Grimling B., Pluta J.

Progress on Chemistry and Application of Chitin and its Derivatives

2012

vol. 17

95 - 102

Connections of polymers and biopolymers with biologically active compounds are recently the subject of intensive research. Low molecular weight active ingredient combined with a polymer has, in many cases, the modified action. On the other hand, the use of inappropriate polymers can result in incompatibilities drug-polymer. The phenomenon of adsorption of the antibiotic has been studied by the static method in the concentration range generally taken single dose using a pharmaceutical gastrointestinal tract model. The results of measurements bounded drug quantity were used to determine the average percentage of adsorbed dose. The results show that antibiotic tiamphenicol is adsorbed on chitosan in used pH ranges, and the binding ability depends on the variety of chitosan and directly from the environment reaction. It was observed that the average sorption depending on the type of chitosan was within the limit from 82% to 97%.The fact of the lowest adsorption value at pH 6.4 can be explained by chemical properties of chitosan, which shows the load until the pH > 6.7 and the electrostatic adsorption may be exhibit in relation to weak acid medicinal substance. Thus, the specific polymer surface area and its sorption capacity is increased. Based on the above considerations can be stated that between study drug and the polymer an antagonistic interaction exist by involving the adsorption of drugs from this group on chitosan.

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1 Progress on Chemistry and Application of Chitin and its Derivatives

1 2012

1 Grimling B.

1 Meler J.

1 Pluta J.

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STUDIES ON ADSORPTION TIAMFENICOL ON CHITOSANS DEGRADED RADIATION IN PHARMACEUTICAL IN VITRO MODEL