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INFLUENCE OF HYDROPHILIC POLYMERS ON THE PROPERTIES OF GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2015
|
vol. 20
195-203
EN
Tested impact of polyvinyl alcohol, dextrane and calcium alginate for the properties of the powders containing poloxamer 407 and lactic acid complexed with chitosan. For researches was prepared formulations with different pH and rheological properties. The thermosensitive gels obtained from thermosensitive powders possess the work of adhesion with different values. The researches revealed that the dynamic viscosity of the gels obtained from powders is high. A wide range of pH of the thermosensitive gels allows the selection of the optimum formulation. The gels obtained from the powders containing polyvinyl alcohol or dextrane or calcium alginate were characterized by the specific dynamic viscosity. The researches demonstrated that the methylcellulose with different values of the viscosity with poloxamer 407 significantly affect the adhesive properties of thermosensitive hydrophilic gels obtained from powders.
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THE PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2015
|
vol. 20
183-194
EN
The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol resulted in increased pH of the formulations. A modification of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol has increased the range of the dynamic viscosity of formulations. The enrichment of the composition of the tested powders containing 5% hydroxypropylmethylcellulose resulted in increased the range of the dynamic viscosity and decreased pH of the formulations. Laboratory tests have shown that it is possible to obtain thermosensitive gels with high adhesion properties to vaginal mucous membrane.
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