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OLEOGELS AND BIGELS AS TOPICAL DRUG CARRIERS FOR KETOCONAZOLE – DEVELOPMENT AND IN VITRO CHARACTERIZATION

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Wróblewska M., Szekalska M., Hafner A., Winnicka K.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 3
EN
Abstract: The purpose of this study was to develop and characterize novel gel formulations of oleogels and oleo-hydrogels (bigels) as topical drug delivery systems for ketoconazole (KET). Oleogels were prepared using paraffin oil, rapeseed oil or castor oil as a solvent and Aerosil® 200 as organogelator with addition of surfactant Tween 80. Bigels were prepared by mixing castor oil oleogels with sodium alginate hydrogel. The received formulations were analyzed microscopically, for pH, viscosity and the texture profile analysis was also conducted to examine the mechanical parameters. In addition, the in vitro release of KET was evaluated and ex vivo bioadhesive properties of obtained oleogels and bigels on the rat skin model were estimated. It was found that obtained formulations were non-Newtonian systems, showing a shear-thinning behavior and thixotropic properties, with proper textural features such as firmness, compressibility, adhesiveness. Moreover, they were characterized by beneficial bioadhesive properties. Prepared oleogels and bigels were considered as better formulations in terms of drug release compared to commercially available ketoconazole cream.
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Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses

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Izquierdo-Barba I., Vallet-Regí M.
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vol. 1
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issue 1
EN
In the last decade, the development of third generation bioceramics for Bone Tissue Regeneration has experienced significant progress with the emergence of a new generation of nanostructured materials named mesoporous bioactive glasses (MBG). This new generation of materials, also known as “templated glasses”, presents chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. This article shows an indepth comparative study of the ordered porous structures of MBGs compared to conventional glasses (melt and solgel) andhowthese properties influence the bioactivity process. Moreover, the possibility to tailor the textural and structural properties of these nanostructured materials by an exhaustive control of the different synthesis parameters is also discussed. A brief overview regarding the possibility of using these materials as controlled drug delivery systems and as starting materials for the fabrication of 3D scaffolds for bone tissue regeneration is also given.
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