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In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.

100%

Kryczka T., Bero M., Kasperczyk J., Dobrzyński P., Marciniec B., Popierzal-Brzezińska M., Grieb P.

2002

vol. 49

issue 1

205-210

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.

Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment

88%

Puač N., Miletić M., Mojović M., Popović-Bijelić A., Vuković D., Miličić B., Maletić D., Lazović S., Malović G., Petrović Z. L.

Open Chemistry

2015

vol. 13

issue 1

In this paper we will present results for plasma sterilization of planktonic samples of two reference strains of bacteria, Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 29212. We have used a plasma needle as a source of non-equilibrium atmospheric plasma in all treatments. This device is already well characterized by OES, derivative probes and mass spectrometry. It was shown that power delivered to the plasma is bellow 2 W and that it produces the main radical oxygen and nitrogen species believed to be responsible for the sterilization process. Here we will only present results obtained by electron paramagnetic resonance which was used to detect the OH, H and NO species. Treatment time and power delivered to the plasma were found to have the strongest influence on sterilization. In all cases we have observed a reduction of several orders of magnitude in the concentration of bacteria and for the longest treatment time complete eradication. A more efficient sterilization was achieved in the case of gram negative bacteria.

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1 Acta Biochimica Polonica

1 Open Chemistry

1 2014

1 2002

1 Bero M.

1 Dobrzyński P.

1 Grieb P.

1 Kasperczyk J.

1 Kryczka T.

1 Lazović S.

1 Maletić D.

1 Malović G.

1 Marciniec B.

1 Miletić M.

1 Miličić B.

1 Mojović M.

1 Petrović Z. L.

1 Popierzal-Brzezińska M.

1 Popović-Bijelić A.

1 Puač N.

1 Vuković D.

Search results

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.

Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment