Search results

1

Application of the sentinel lymph node biopsy technique in laryngological oncology

100%

Krawczyk P. H., Marcin B., Kaczmarczyk D., Morawiec-Sztandera A.

Polski Przegląd Otorynolaryngologiczny

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2017

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vol. 6(2)

42-49

EN

Neoplasms of the head and neck stands for 6th most common malignant neoplasms in terms of morbidity in Poland. The effectiveness of the treatment depends on the complete resection and presence of the lymphatic metastases, detection of which might not be possible at the moment of diagnosis. Routine performance of the elective neck dissection among patients without lymphadenopathy (cN0) may favour the occurrence of surgical complication and seems to be too invasive procedure, particularly in group with non-advanced tumours (cT1-2). The sentinel lymph node biopsy is diagnostic procedure, which allows to exclude presence of metastases in nodes draining lymph directly from primary tumour. This technique let for a limitation of the extent of the procedure and the evaluation of the lymphatic tissue under the microscope in order to exclude presence of neoplastic cells. Sentinel lymph node biopsy is commonly use among patients with malignant melanoma of the skin and breast cancer. Multiple studies prove its usefulness during treatment of patients with head and neck cancer.

2

A suspicious non-healing wound of the pinna

100%

Nasir M. S. N. M., Yusof S., Bakar M. N. A., Mohamad I.

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vol. 14

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issue 4

425-427

EN

Squamous cell carcinoma of the pinna occurs primarily in older males who are exposed to sunlight for a prolonged period. Most squamous cell carcinomas of the pinna are well differentiated and present as a painless mass or a sessile nodule. We describe an interesting case of an adult woman with a non-healing wound located on the right pinna which was treated conservatively, and was later diagnosed as squamous cell carcinoma.

PL

Rak kolczystokomórkowy skóry zlokalizowany w obrębie małżowiny usznej występuje głównie u mężczyzn w starszym wieku, którzy są narażeni na długotrwałe działanie promieni słonecznych. W większości przypadków nowotwór ten jest dobrze zróżnicowany i ma postać niebolesnej masy lub nieuszypułowanego guzka. W pracy opisujemy ciekawy przypadek dorosłej kobiety z niegojącą się raną prawej małżowiny usznej – pacjentkę leczono zachowawczo, zanim ustalono rozpoznanie raka kolczystokomórkowego.

3

A suspicious non-healing wound of the pinna

100%

Nasir M. S. N. M., Yusof S., Bakar M. N. A., Mohamad I.

|

vol. 14

|

issue 4

425-427

EN

Squamous cell carcinoma of the pinna occurs primarily in older males who are exposed to sunlight for a prolonged period. Most squamous cell carcinomas of the pinna are well differentiated and present as a painless mass or a sessile nodule. We describe an interesting case of an adult woman with a non-healing wound located on the right pinna which was treated conservatively, and was later diagnosed as squamous cell carcinoma.

PL

Rak kolczystokomórkowy skóry zlokalizowany w obrębie małżowiny usznej występuje głównie u mężczyzn w starszym wieku, którzy są narażeni na długotrwałe działanie promieni słonecznych. W większości przypadków nowotwór ten jest dobrze zróżnicowany i ma postać niebolesnej masy lub nieuszypułowanego guzka. W pracy opisujemy ciekawy przypadek dorosłej kobiety z niegojącą się raną prawej małżowiny usznej – pacjentkę leczono zachowawczo, zanim ustalono rozpoznanie raka kolczystokomórkowego.

4

Association between clinical stage of oral cancer and expression of immunohistochemical markers

100%

Świątkowski W., Rahnama M., Tomaszewski T., Bigas M., Świątkowska A., Łobacz M., Wallner J.

Polish Journal of Surgery

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2017

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vol. 89(6)

17-22

EN

Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease. Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. The methods: Immunohistochemical analysis using the detection system DAKO K5007 Cat - Dako REAL ™ Detection System, Peroxidase DAB +, Rabbit / Mouse. Results: Based upon the statistical results, significant correlation between p53 protein and tumor staging; however, a correlation between the level of expression of EGFR, p44/42, PCNA and staging was not likewise revealed. Conclusions: Looking for oral squamous cell carcinoma markers remains an actual issue. Identification of specific markers of oral cancer could be used in screening the population, determining prognosis and response to treatment.

5

Difficulties in clinical staging of external ear canal carcinoma– a case report

100%

Żurek M., Rzepakowska A., Niemczyk K.

Polski Przegląd Otorynolaryngologiczny

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2018

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vol. 7(1)

45-50

EN

Carcinoma of the external auditory canal (EAC) is known to be very rare with a rate of 1-6 per million people. It affects mostly people over the age of 50 regardless of gender. The most common type of carcinoma of EAC is squamous cell carcinoma (SCC). The aim of this paper is to present the case of a 56-year-old woman with carcinoma of EAC. She was admitted to otolaryngology clinic due to ear buzzing lasting for five months, periodic otorrhea and hearing deterioration in her right ear. In otoscopic examination a tumor in the right ear meatus was identified. It filled almost the entire canal. Biopsy confirmed the presence of squamous-cell cancer. Tumor advancement was diagnosed using computer tomography of the temporal bones, magnetic resonance imaging of the head and ultrasonography of the neck. Imaging examinations indicated T3 N0 stage. Doctors decided to perform lateral petrosectomy with elective neck dissection. During the operation, the results of histopathological examination of frozen specimens from marginal tissues revealed an invasion of the anterior wall of the ear canal, capsule of temporomandibular joint and parotid gland. The resection eventually included also parotid gland and temporo-mandibular joint with the caput of the mandible. After recuperation, the patient had complementary radiotherapy. The presented case shows that precise imaging is necessary before surgical treatment, but unfortunately the invasion of cancer may not be estimated properly. Based on literature, the best prognosis concerns wide resection with complementary radiotherapy, although the schedule of treatment is not determined.

6

Marjolin's Ulcers as a Consequence of Chronic Venous Ulcers and Chronic Skin Injury - Case Reports

88%

Ciesielczyk B., Murawa D., Nowaczyk P.

Polish Journal of Surgery

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2007

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vol. 79

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issue 10

667-671

EN

In the literature, Marjolin's ulcers are defined as skin cancers that develop secondarily in areas susceptible to an injury, seized by a chronic inflammation or covered by scar tissue.This paper presents three clinical cases of spinocellular carcinoma, which occurred around long-standing venous ulcers or chronic traumatic skin injury within the lower limbs. All the patients had their limbs amputated. No clinical or radiological qualities of lymphadenopathy were diagnosed. The latest checkups indicated the patients' good condition without traits of the neoplastic disease.Managing patients with chronic ulcers, regardless of their aetiology, requires that the doctor should have increased oncological alertness. In this case, one of the most important elements of diagnostics is a regular histopathological assessment of the lesion. Only this procedure enables the early and efficacious surgical treatment of potential secondary neoplastic lesions and possible saving of the limb.

7

Skin of sailor: cutis rhomboidalis nuchae, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Case report

88%

Abdulaziz A., Brzeziński P., Chiriac A.

OncoReview

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2014

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vol. 4

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issue 1

A37-41

EN

Chronic exposure to environmental ultraviolet radiation (UVR) plays a key role both in photocarcinogenesis and induction of accelerated skin ageing. Sailors commonly experience a significant number of cutaneous problems, related to the exposure to environmental factors due to their working conditions. Among these factors, sun exposure is able to determine both acute and chronic skin damage, mostly linked to the effects of the ultraviolet (UV) radiation on epidermal and dermal structures. We report a case of sailor with cutis rhomboidalis nuchae, solar elastosis, actinic keratosis (AK), numerous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) of the head and trunk.

8

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

88%

Sarafian V., Dikov D., Karaivanov M.

Open Medicine

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2006

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vol. 1

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issue 2

119-127

EN

Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of basocellular carcinomas. In spinocellular carcinomas, HBGAs were detected in tumor keratinocytes and in keratin pearls. These results provide new evidence for the differential expression of LAMPs and HBGAs in the normal stratified squamous epithelium, as well as the presence of a modulating reactivity in basocellular and spinocellular carcinomas, suggesting that these glycoproteins are involved in differentiation and tumorigenesis of human skin.

Refine search results

Application of the sentinel lymph node biopsy technique in laryngological oncology

A suspicious non-healing wound of the pinna

A suspicious non-healing wound of the pinna

Association between clinical stage of oral cancer and expression of immunohistochemical markers

Difficulties in clinical staging of external ear canal carcinoma– a case report

Marjolin's Ulcers as a Consequence of Chronic Venous Ulcers and Chronic Skin Injury - Case Reports

Skin of sailor: cutis rhomboidalis nuchae, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Case report

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin