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issue 4
631-634
EN
Introduction: Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO). It was reported that colonic methane production is far more frequent in cystic fibrosis (CF) patients than in other subjects. Therefore, measuring exclusively hydrogen in the diagnostic breath test for diagnosing SIBO might be of limited value. We aimed to assess the usefulness of combined measurement of hydrogen and methane expiration for the diagnosis of SIBO in CF. Material and Methods: The study comprised 62 CF patients aged 5 to 18 years. Three-hundred-ninety subjects assessed due to gastrointestinal symptoms for the presence of SIBO served as a comparative group. In all subjects hydrogen/methane BT using glucose was performed. A positive BT was defined as fasting hydrogen ≥ 20 ppm or fasting methane ≥ 10 ppm or a rise of ≥ 12 ppm hydrogen or ≥ 6 ppm methane over baseline during the test. Results: In 23 (37.1%) CF patients and in 52 (13.3%) subjects from the comparative group abnormal BT results were found. In seven (11.3%) CF patients and 29 (7.4%) of the other subjects studied methane measurement allowed diagnosis of SIBO. Conclusions: Small intestine bacterial overgrowth is frequent in cystic fibrosis. For its detection in cystic fibrosis and other gastrointestinal patients, combined hydrogen and methane measurement instead of hydrogen breath test should be applied. Without the additional measurement of methane a significant percentage of SIBO will be missed.
EN
Although little bacteria colonize upper part of alimentary tract, its microflora is very diverse. In normal conditions intestinal bacteria remain in balance, they constitute barrier, protecting us from infections. Qualitative as well as quantitative disturbance of the microflora has a negative influence on digestion and absorption. Small intestine bacterial overgrowth (SIBO) is defined as an increased number of nonpathogenic bacteria – over 105 organisms in 1 ml of small intestine content. The aim of the study is to assess the frequency of SIBA among children with abdominal symptoms. Material and methods: The study consisted of 83 children (43 girls and 40 boys) aged 4‑17 (mean 11±3.56 years). After excluding organic disorders, hydrogen breath test with lactulose (administered per os) was established among them. Expired air was analysed using Gastrolyzer by Bedfont. Results: Gastrointestinal symptoms were analysed. It appeared that abdominal pain was the most common symptom among 47 (54%) children (among them 27 girls and 20 boys). Eighteen (21%) patients presented additional symptoms that coexisted with abdominal pain. HBT result was positive among 59 (71%) patients – 32 (74%) girls and 27 (68%) boys. Conclusions: Among patients with abdominal pain about 70% presented positive result of HBT.
PL
Mikroflorę jelita charakteryzuje różnorodność gatunków bakterii. W warunkach fizjologicznych skład ontocenozy jelitowej pozostaje w równowadze, a bakterie jelitowe stanowią barierę ochronną przed infekcjami. Zarówno ilościowe, jak i jakościowe zaburzenie mikroflory jelita ma niekorzystny wpływ na proces trawienia i wchłaniania składników pokarmowych. Górna część przewodu pokarmowego kolonizowana jest przez znikomą ilość drobnoustrojów. Wzrost liczby niepatogennych bakterii powyżej 105 komórek bakteryjnych w mililitrze treści jelitowej w początkowym odcinku jelita cienkiego określa się jako dysbakteriozę lub rozrost bakteryjny jelita. Celem pracy jest ocena częstości występowania dysbakteriozy jelitowej u dzieci z dolegliwościami brzusznymi. Materiał i metody: Badaniem objęto 83 dzieci (43 dziewczynki i 40 chłopców) w wieku od 4 do 17 lat (średnia 11±3,56 roku) z dolegliwościami ze strony przewodu pokarmowego. Po wykluczeniu zmian organicznych wykonywano wodorowy test oddechowy (hydrogen breath test, HBT) po doustnym obciążeniu laktulozą. Powietrze wydechowe oceniano za pomocą aparatu Gastrolyzer firmy Bedfont. Wyniki: Przeanalizowano dolegliwości zgłaszane przez pacjentów. Dominującym objawem u 47 (56%) badanych dzieci były bóle brzucha (27 dziewczynek i 20 chłopców); u 18 (21%) należały one do współistniejących objawów. HBT był dodatni u 59 (71%) badanych, w tym u 32 (74%) dziewczynek i 27 (68%) chłopców. Wniosek: W grupie pacjentów z dolegliwościami bólowymi brzucha rozpoznawana częstość przerostu flory bakteryjnej jelita cienkiego wynosi około 70%.
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