Search results

1

Differences in Tibiocalcaneal Kinematics Measured with Skin- and Shoe-Mounted Markers

100%

Sinclair J., Greenhalgh A., Taylor P. J., Edmundson C. J., Brooks D., Hobbs S. J.

Human Movement

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2013

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vol. 14

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issue 1

64-69

EN

Purpose. The aim of the current investigation was to compare the 3-D tibiocalcaneal kinematics between skin- and shoe-mounted markers. Methods. Eleven male participants ran at 4.0m/s ± 5% along a 22 m runway. Tibiocalcaneal kinematics were captured simultaneously using markers placed externally on the shoe and on the skin through windows cut in the shoe. Paired t-tests were used to compare the 3-D kinematic parameters, and intraclass correlations were employed to contrast the kinematic waveforms. Results. Strong correlations were observed between the waveforms at R2 0.85. However, foot movements such as eversion range of motion, peak eversion, peak transverse plane range of motion, velocity of external rotation and peak eversion velocity were all significantly underestimated using shoe-mounted markers. Conclusions. The results indicate that shoe-mounted markers do not fully represent true foot movement.

2

The influence of an opioid on the course of reparative processes

100%

Mateshuk-Vatseba L., Diskovskyi I.

Current Issues in Pharmacy and Medical Sciences

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2015

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vol. 28

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issue 1

46-50

EN

The objective of our work is to examine the influence of prolonged administration of an opioid, on the course of the reparative process of a multiple post-injection wound inflicted upon a white rat’s skin, doing so by way of using light microscopy. The studies were carried out on 24 mature white male rats, aged 4.5-7.5 months, with weights of 130-150 g. For histological examination, the skin sections were stained with hematoxylin and eosin. The preparations were studied and photographed at the magnification of ob.х8, ey.x15 and ob.x40, ey.x10. The «Aver Media» computer system was employed for micropreparations photography. The set levels of light microscopy reveal that the administration of an opioid for a 2 week period does not affect the reparative process of a multiple post-injection wound. Moreover, in most wound canals, the formation of a complete regenerate can be seen. However, after 4 weeks of nalbufin administration, the processes of wound healing slowed and were complicated by the formation of microabscesses. After 6 weeks of opioid administration, destructive changes in the skin were detected. These, in turn, led to the incomplete regenerate formation in the multiple postinjection wound. The experimental results, hence, show the negative effect of prolonged administration of opioid on the reparative processes in the skin.

3

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

88%

Sarafian V., Dikov D., Karaivanov M.

Open Medicine

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2006

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vol. 1

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issue 2

119-127

EN

Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of basocellular carcinomas. In spinocellular carcinomas, HBGAs were detected in tumor keratinocytes and in keratin pearls. These results provide new evidence for the differential expression of LAMPs and HBGAs in the normal stratified squamous epithelium, as well as the presence of a modulating reactivity in basocellular and spinocellular carcinomas, suggesting that these glycoproteins are involved in differentiation and tumorigenesis of human skin.

4

Tigecycline - A New Antibiotic in Infections Treatment

88%

Stefaniuk E., Hryniewicz W.

Polish Journal of Surgery

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2007

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vol. 79

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issue 9

587-593

EN

Tigecycline, a member of a new class of antimicrobials (glycylcyclines), was shown to have expanded broad spectrum activity against most commonly encountered species responsible for community and hospital acquired infections, including Gram-positive and Gram-negative multidrug resistant bacterial strains.The aim of the study was to evaluate the activity of tigecycline against resistant bacterial strains commonly associated with nosocomial infections, including skin structure, subcutaneous layer and intra-abdominal infections.Material and methods. Ten general hospitals from different regions of Poland participated in the study. Antimicrobial susceptibility tests were carried for 539 isolates of different genus/species of bacterial strains isolated from patients hospitalized in hospitals throughout Poland. Minimal inhibitory concentrations (MICs) of tigecycline were determined using the broth dilution method.Results. Ten strains of 50 S. aureus isolates, i.e. 20%, were methicillin-resistant (MRSA). The lowest MIC90 values observed for tigecycline were (0.25 μg/ml); they were similar to the MIC50 for MSSA and MRSA.S. pneumoniae varied with respect to their susceptibility to penicillin. Twenty two percent of isolates (n=11) had decreased susceptibility to penicillin. However, all 50 strains of this species were susceptible to levofloxacin, vancomycin and linezolid. Tigecycline exhibited high activity against S. pneumoniae strains. Tigecycline MIC90 values for this group of strains were lower than MIC90 of the remaining antibiotics. One hundred percent of collected S. agalactiae strains were susceptible to all investigated antibiotics.Conclusion. The presented data indicate that tigecycline exhibits excellent inhibitory activity against nosocomial and community pathogens regardless of resistance patterns.

5

Vitamin D in the skin physiology and pathology

88%

Piotrowska A., Wierzbicka J., Żmijewski M.

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2016

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vol. 63

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issue 1

17-29

EN

Vitamin D plays important, pleiotropic role in the maintenance of global homeostasis. Its influence goes far beyond the regulation of calcium and phosphorus balance, as diverse activities of vitamin D and its natural metabolites assure proper functioning of major human organs, including skin. Recently, we reviewed the current understanding of vitamin D impact on human health from historical perspective (Wierzbicka et al. (2014) The renaissance of vitamin D. Acta Biochim Pol 61: 679-686). This article focuses on its functions in the skin. The skin and its appendages, creates a platform connecting and protecting internal organs against, usually harmful, external environment. It uppermost layer - epidermis in order to maintain a protective barrier undergoes a constant exchange of cornified keratinocytes layer. Its disturbance leads to development of serious skin disorders including psoriasis, vitiligo, atopic dermatitis and skin cancer. All of those dermatopathologies have a huge impact on modern societies, affecting not only the physical, but also mental state of patients as well as their social status. Furthermore, multiple human systemic diseases (autoimmune, blood and digestive diseases) have skin manifestation, thus "condition of the skin" often reflects the condition and pathological changes within the internal organs. In humans, the skin is the natural source of vitamin D, which is produced locally from 7-dehydrocholesterol in photoreaction induced by ultraviolet B (UVB) radiation from the sun. It is also well established, that the process of proliferation and differentiation of keratinocytes is tightly regulated by calcium and the active form of vitamin D (1,25(OH)2D3). Thus, the skin physiology is inseparably connected with vitamin D production and activity. Unfortunately, UVB, which is required for vitamin D production, is also known as the main cause of a skin cancer, including melanoma. Here, we are going to review benefits of vitamin D and its analogues in the maintenance of epidermal barrier and its potential use in the treatment of common skin diseases.

6

The renaissance of vitamin D

88%

Wierzbicka J., Piotrowska A., Żmijewski M.

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2014

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vol. 61

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issue 4

679-686

EN

There is no doubt that vitamin D plays a crucial role in the maintenance of musculoskeletal system. But the function of this ancient molecule presumably ranges far beyond hormone-like regulation, as it could be generated by simple unicellular organisms. First, we are going to discuss the role of vitamin D as a global regulator of homeostasis from a historical perspective, but later we will focus on current views and its relevance to human physiology and pathology. Three milestones are defining the impact of vitamin D on science and humanity. Firstly, discovery that vitamin D is the cure for rickets, brought us supplementation programs and rapid irradiation of this devastating disease. Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Finally, recent large epidemiological studies provided indirect, but strong evidence that optimal level of vitamin D in serum has beneficial effects on our health and protects us from multiple diseases, including cancer. Furthermore, existence of alternative pathways of vitamin D metabolism and multiple intracellular targets broadens our understanding of its physiological activities and offers new and very promising tools for prophylactics and treatment of many diseases of civilization. Although vitamin D (and its derivatives) should not be regarded as a cure-all for every human disease, its beneficial effects on the human health have to be taken under consideration.

7

Gas gangrene as a surgical emergency – own experience

75%

Zaręba K. P., Dawidziuk T., Zińczuk J., Pryczynicz A., Guzińska-Ustymowicz K., Kędra B.

Polish Journal of Surgery

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2019

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vol. 91(6)

1-5

EN

In this paper the authors would like to present a correct procedure in both surgical and hyperbaric treatment of patients with gas gangrene admitted to a surgical department during ER. Gas gangrene is not very common these days, but when it comes to dealing with gangrenous infection in the emergency it is quite likely to make errors in both diagnostic and therapeutic manners. When there is a gas gangrene in a patient at the emergency time plays crucial role and the proper application of procedures is vital for the patient’s survival. 10 cases made the study group here, all of them were patients diagnosed and treated surgically due to gas gangrene. As shown here, It is important to perform a revision of surgical wounds after few hours since primary surgery and to begin hyperbaric treatment as quickly as possible. The findings and suggestions included in this study are supported by own experience of The 2nd Department of General and Gastrointestinal Surgery of Medical University in Białystok, Poland.

8

The Influence of Concentration of Acetic Acid and Pepsin Enzyme in Nilem Fish Skin Collagen Extractionto the Amount of Rendement Produced

75%

Junianto J., Iskandar I., Rizal A., Damayanti W.

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vol. 21

164-170

EN

The added value of nilem fish skin needs to be increased. The purpose of this study is to determine the concentration of acetic acid solution combined with the pepsin enzyme in the extraction of collagen from nilem fish skin that is necessary to obtain the highest yield/renderment. The study employed an experimental research method that used a completely randomized factorial design. The first treatment is the concentration of acetic acid solution. This consists of three levels, namely 0.5M, 0.7M and 0.9M. The second treatment is the concentration of the enzyme pepsin. This in turn consists of three levels, namely 0.5 %, 1.0 % and 1.5% (weight / weight). The parameters observed were collagen renderment. The results showed that the combination treatment concentration of 0.7 M solution of acetic acid by the pepsin enzyme at 1.0%, in the extraction of collagen from fish skin, produce the highest yield compared to other combinations. The renderment yield is 6.18%.

9

Selected therapeutic methods affecting the health and quality of life of chronically dermatologically ill people

75%

Ścisłowska-Czarnecka A., Matuła A., Bac A., Lizak A., Wilk M.

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EN

The skin is one of the first organs that manifest disorders of homeostasis occurring in the body. Chronic diseases that manifest themselves as skin problems are often associated with severe stress and the accompanying anxiety, uncertainty and pain, which consequently reduce the quality of patients’ lives. Both stress and dermatoses trigger a cycle of neurohormonal reactions in the body that affects the functioning of the nervous, endocrine and immune systems. The data presented in this article indicate a relationship between stress, the functioning of the immune system and the quality of life of patients with chronic dermatological diseases. The article stresses the necessity of a holistic approach to skin problems in cosmetology, which is a very important element of its care and can decrease stress. Therefore, we believe that care and beauty treatments in combination with aromatherapy and music therapy can complement classical therapy. By reducing stress levels and improving the patient’s health, they can increase the quality of life.

10

Therapeutic activity of chlorhexidine-poloxamer antiseptic gel on wound healing in rats: a preclinical study

75%

Babickaite L., Grigonis A., Ramanauskiene K., Matusevicius A. P., Zamokas G., Daunoras G., Ivaskiene M.

Polish Journal of Veterinary Sciences

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2018

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vol. 21

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issue 1

11

Skóra – najważniejszy narząd naszego ciała. Dbajmy o nią!

63%

Sybilski A. J.

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issue 4

375-379

EN

The skin is the largest and the most important organ of our body, meets a number of key functions: passive (protection) and active (secretory, sensory). We have to take care of it even, when it is healthy and to prevent the disease. Primary care is the proper cleaning and moisturizing. It should also protect against abrasions. It should not be overexposed to the UV radiation, low or high temperatures, wind and high humidity. Adverse effects on the skin are also irritants. The specific structure of the skin of newborns and infants necessitates constant, very careful and thorough skin care and rapid response in the event of even a minor irritation and damage. The safest cosmetic products for infants are mild, pH‑neutral cleaner with no added colours or fragrances. Do not forget about protection from sunlight and use sunscreen regularly. In teenage skin we have problems with tattoos, piercings, excessive flaming in solariums. These situations have a very negative effect on the skin and require special care. The daily skin care of adults is necessary. We must use a systematic and continuous creams tailored to the age, health of the skin and the conditions in which we live. Skin care should be a daily habit. Choosing skin care products should be guided by three principles: it should be tailored to the age and needs of your skin, do not contain preservatives and fragrances, should be affordable, so we can use it every day.

PL

Skóra to najważniejszy i największy narząd naszego ciała, spełniający wiele kluczowych funkcji, które dzieli się na bierne (ochrona) oraz czynne (wydzielnicza, czuciowa). Należy o nią dbać nawet wtedy, gdy jest zdrowa, aby zapobiegać jej chorobom. Podstawowa pielęgnacja obejmuje właściwe jej oczyszczanie i nawilżanie. Trzeba ją również chronić przed otarciami i odparzeniami, nie powinno się jej nadmiernie eksponować na promieniowanie UV, niską lub wysoką temperaturę, wiatr, a także wysoką wilgoć. Niekorzystne dla skóry są również środki drażniące. Swoista budowa skóry noworodków i niemowląt wymusza stałą, bardzo ostrożną i dokładną pielęgnację skóry zdrowej i szybką reakcję w przypadku wystąpienia nawet niewielkich podrażnień i uszkodzeń. Najbezpieczniejsze są łagodne produkty kosmetyczne, o neutralnym pH, środki czyszczące bez dodatku barwników lub substancji zapachowych. Nie wolno zapomnieć o ochronie przed promieniowaniem słonecznym i stosować regularnie kremy z filtrem. U młodzieży problemem dla skóry mogą być tatuaże, kolczyki, nadmierne opalanie w solariach. Sytuacje te bardzo negatywnie wpływają na skórę i wymagają szczególnej pielęgnacji. W codziennej pielęgnacji skóry dorosłych niezbędne jest systematyczne i stałe używanie kremów dostosowanych do wieku, stanu zdrowia skóry oraz warunków życia. Dbanie o skórę powinno być nawykiem. Przy wyborze preparatów pielęgnacyjnych należy zwrócić uwagę, by były dopasowane do wieku i potrzeb skóry, nie zawierały konserwantów ani substancji zapachowych, ich cena nie obciążała zbytnio budżetu i umożliwiała codzienne stosowanie.

12

Piękno w tabletce – wiedza społeczeństwa na temat nutraceutyków

63%

Karkoszka M., Banach K., Beberok A., Wrześniok D. M.

Farmacja Polska

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2020

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vol. 76

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issue 5

239-249

EN

SUBJECT OF RESEARCH: Nutricosmetics contain vitamin, mineral and biologically active compounds that have a positive effect on the appearance of the skin, nails and hair. The constantly growing consumption of dietary supplements, including preparations improving the condition of the skin of the hair and nails, promotes the creation of new preparations, but does not increase public awareness of the products used. RESEARCH OBJECTIVE: The aim of the study was to verify patients' knowledge of dietary supplements, with particular emphasis on preparations improving the condition of skin, hair and nails, as well as determining the factors determining the choice of a particular preparation. MATERIALS AND METHODS: The survey was conducted from December 2019 to April 2020 with the participation of a random group of 170 respondents, using the author's anonymous questionnaire containing 33 questions. RESULTS: Based on the results obtained, it can be said that 95% of respondents know the definition of a dietary supplement, but only 46.5% of respondents know that they are intended for healthy people, 54% of respondents declare taking dietary supplements that support the condition of the skin, hair and nails, 1/3 of respondents when choosing a preparation do not pay attention to whether it is a medicine or a dietary supplement, and 40% of respondents are not aware of the differences resulting from the different registration of both preparations. Over 70% of respondents buy dietary supplements at the pharmacy, but only a quarter of respondents use the pharmacist's professional advice. Almost 40% of respondents simultaneously use two or more dietary supplements, without being aware of the possibility of overdose of active substances contained in the preparations taken. Only half of the respondents are satisfied with the effects achieved thanks to the use of dietary supplements that improve the condition of the skin, hair and nails. CONCLUSIONS: Respondents have basic knowledge about dietary supplements used, but constant public education is needed regarding specialist knowledge regarding the quality and method of taking dietary supplements.

PL

PRZEDMIOT BADAŃ: Nutrikosmetyki zawierają związki witaminowe, mineralne i biologicznie aktywne, które wpływają korzystnie na wygląd skóry, paznokci i włosów. Stale rosnąca konsumpcja suplementów diety, w tym preparatów poprawiających kondycję skóry włosów i paznokci sprzyja powstawaniu nowych preparatów, jednak nie zwiększa to świadomości społeczeństwa w zakresie stosowanych produktów. CEL BADAŃ: Celem badania była weryfikacja wiedzy pacjentów na temat zażywanych suplementów diety, ze szczególnym uwzględnieniem preparatów poprawiających kondycję skóry, włosów i paznokci, a także określenie czynników, determinujących wybór określonego preparatu. MATERIAŁY I METODY: Badanie prowadzono od grudnia 2019 do kwietnia 2020 roku z udziałem losowej grupy 170 respondentów, za pomocą autorskiego, anonimowego kwestionariusza zawierającego 33 pytania. WYNIKI: Na podstawie uzyskanych wyników można stwierdzić, iż 95% respondentów zna definicję suplementu diety, jednak tylko 46,5% ankietowanych wie, że są one przeznaczone dla osób zdrowych, 1/3 respondentów podczas wyboru preparatu nie zwraca uwagi czy jest on lekiem czy suplementem diety, a 40% badanych nie ma świadomości różnic wynikających z odmiennej rejestracji obu preparatów. Ponad 70% badanych kupuje suplementy diety w aptece, jednak z fachowej porady farmaceuty korzysta jedynie ¼ respondentów. Niemal 40% ankietowanych stosuje jednocześnie dwa lub więcej suplementów diety, nie będąc świadomymi możliwości przedawkowania substancji czynnych zawartych w przyjmowanych preparatach. Jedynie połowa badanych jest zadowolona z efektów osiągniętych dzięki stosowaniu suplementów diety poprawiających kondycję skóry, włosów i paznokci. WNIOSKI: Respondenci posiadają podstawową wiedzę na temat stosowanych suplementów diety, jednak konieczna jest stała edukacja społeczeństwa w zakresie specjalistycznej wiedzy dotyczącej jakości i sposobu przyjmowania suplementów diety.

13

Ultrasonograficzny obraz skóry, aparatura i podstawy obrazowania

51%

Mlosek R. K., Malinowska S.

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vol. 13

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issue 53

212-221

EN

Ultrasound imaging of the skin is becoming more and more popular. Skin ultrasound examinations are used both in order to assess healthy skin and to evaluate pathological lesions. They are mainly performed in dermatology as well as in broadly understood aesthetic medicine and cosmetology. At present, skin imaging is enabled by high-frequency equipment and high-quality conventional devices. The introduction of high-frequency electronic transducers which are supported by conventional scanners may be a turning point in skin ultrasound equipment. Irrespective of the ultrasound scanner, three layers may be distinguished in the image of the healthy skin: epidermal echo, dermis and subcutaneous tissue. High-frequency equipment allows for detailed imaging of the epidermal echo, dermis and upper part of the subcutaneous tissue. It is also possible to visualize the skin appendages (hair with follicles and nails) as well as slight vessels that run in the dermis and upper subcutaneous tissue. Contrary to high-frequency equipment, conventional scanners do not allow for a detailed assessment of the epidermal and dermal echoes. Instead, they enable the visualization of the entire subcutaneous tissue. The following parameters are used for the assessment of skin ultrasound images: thickness of individual skin layers, caliber of blood vessels, echogenicity of the dermis or its individual layers, echogenicity of the subcutaneous tissue as well as the presence or absence of flow in slight venous vessels. Currently, the studies on the usage of sonoelastography for skin assessment are in progress. Considering the dynamic development of skin imaging equipment and its diagnostic possibilities, one might suspect that high-frequency examinations will become more common and will be fundamental for the evaluation of both healthy and pathologically altered skin. This paper is an introduction to a series of articles on the clinical application of high-frequency ultrasound. The next articles will be published in the subsequent issues.

PL

Ultrasonograficzne obrazowanie skóry staje się coraz bardziej popularne. Badania ultrasonograficzne skóry znajdują zastosowanie zarówno w ocenie skóry zdrowej, jak i zmienionej chorobowo i są wykorzystywane przede wszystkim na gruncie dermatologii oraz szeroko rozumianej medycyny estetycznej i kosmetologii. Obecnie obrazowanie skóry możliwe jest przy wykorzystaniu aparatów wysokich częstotliwości oraz wysokiej klasy aparatów klasycznych. Przełomem w aparaturze do ultrasonograficznego badania skóry może być wprowadzenie do użycia wysokoczęstotliwościowych głowic elektronicznych, które współpracują z klasycznymi aparatami. Na obrazie skóry zdrowej bez względu na typ zastosowanego ultrasonografu wyróżniamy trzy warstwy: echo naskórka, skórę właściwą i tkankę podskórną. Aparaty wysokich częstotliwości umożliwiają szczegółowe obrazowanie echa naskórka, skóry właściwej i górnej części tkanki podskórnej. Możliwe jest również obrazowanie przydatków skóry (włosy wraz z mieszkami włosowymi, paznokcie) oraz drobnych naczyń krwionośnych biegnących w skórze właściwej i górnej części tkanki podskórnej. W ultrasonografach klasycznych, w porównaniu z aparatami wysokich częstotliwości, nie ma możliwości szczegółowej oceny echa naskórka i skóry właściwej. W zamian istnieje możliwość zobrazowania całej tkanki podskórnej. Do oceny ultrasonograficznych obrazów skóry wykorzystuje się następujące parametry: pomiary grubości poszczególnych warstw skóry, pomiar średnicy naczyń krwionośnych, pomiar echogeniczności skóry właściwej lub jej poszczególnych warstw, pomiar echogeniczności tkanki podskórnej, brak lub obecność przepływu w drobnych naczyniach żylnych. Aktualnie trwają prace nad wykorzystaniem do oceny skóry sonoelastografii. Biorąc pod uwagę dynamiczny rozwój aparatów do obrazowania skóry i ich możliwości diagnostyczne, można przypuszczać, że badania wysokich częstotliwości upowszechnią się i będą podstawą w ocenie skóry zarówno zdrowej, jak i zmienionej chorobowo. Praca stanowi wstęp do cyklu artykułów o klinicznych zastosowaniach ultrasonografii wysokich częstotliwości, które będą omawiane na łamach kolejnych numerów.

Refine search results

Differences in Tibiocalcaneal Kinematics Measured with Skin- and Shoe-Mounted Markers

The influence of an opioid on the course of reparative processes

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

Tigecycline - A New Antibiotic in Infections Treatment

Vitamin D in the skin physiology and pathology

The renaissance of vitamin D

Gas gangrene as a surgical emergency – own experience

The Influence of Concentration of Acetic Acid and Pepsin Enzyme in Nilem Fish Skin Collagen Extractionto the Amount of Rendement Produced

Selected therapeutic methods affecting the health and quality of life of chronically dermatologically ill people

Therapeutic activity of chlorhexidine-poloxamer antiseptic gel on wound healing in rats: a preclinical study

Skóra – najważniejszy narząd naszego ciała. Dbajmy o nią!

Piękno w tabletce – wiedza społeczeństwa na temat nutraceutyków

Ultrasonograficzny obraz skóry, aparatura i podstawy obrazowania