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  1. 1 Open Chemistry

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  1. 1 2004

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  1. 1 Kurteva V.

  2. 1 Lyapova M.

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Synthesis of a series of vicinal diamines with potential biological activity

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Kurteva V., Lyapova M.
Open Chemistry
|
2004
|
vol. 2
|
issue 4
686-695
EN
A broad range of vicinal diamines based on styrene oxide are synthesisedvia mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds are in progress.
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