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THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE

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Zalewski P., Kilińska K., Piontek J. C., Skibiński R., Szymanowska D., Miklaszewski A., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 5
1127-1133
EN
The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods, although the presence of free radicals (7.7*1017 radicals/g) was detected by EPR. The antibacterial activity of doripenem irradiated with a dose of 25 kGy was unchanged. Solid doripenem has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
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THE RADIATION STERILIZATION OF IMIPENEM AND CILASTATIN IN THE SOLID STATE

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Zalewski P., Kilińska K., Piontek J. C., Miklaszewski A., Szymanowska D., Skibiński R., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 3
431-438
EN
One of the best sterilization methods for chemically unstable drugs, such as carbapenems, is irradiation. The chemical and physical properties of radiosterilized imipenem and cilastatin were analyzed using spectrophotometric and chromatographic methods. Unstable free radicals were presented in samples after irradiation; their mean lifetime was 142±64 h. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy changed for Klebsiella pneumoniae and Escherichia coli. Imipenem and cilastatin in the solid state are not resistant to radiation sterilization; therefore, this method cannot be used for sterilization of this compound.
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THE RADIOSTABILITY OF BETAMIPRON IN THE SOLID STATE

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Zalewski P., Kilińska K., Cielecka-Piontek J., Skibiński R., Miklaszewski A., Bednarski W.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 4
629-634
EN
The influence of ionising radiation on physicochemical properties of betamipron in solid state was studied. No changes for betamipron irradiated with a dose of 25 kGy, required to attain sterility, was observed by spectroscopic and chromatographic methods. Solid betamipron has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
4
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The radiolytic studies of panipenem in the solid state

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Zalewski P., Rosiak N., Kilińska K., Skibiński R., Szymanowska D., Tykarska E., Piekara-Sady L., Lewandowska K., Miklaszewski A., Piontek J. C.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 2
241-250
EN
The influence of ionizing radiation on the physicochemical properties of panipenem in solid state was studied. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile panipenem. Spectroscopic (FT-IR, Raman), chromatography (HPLC and HPLC-MS) and X-ray powder diffraction (XRPD) studies have shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of panipenem irradiated with the dose of 25 kGy was reduced for three species. It was confirmed that the decrease in antimicrobial activity might be related to isomerization of panipenem.
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