Search results

Search:
in the keywords: quaternized chitosan

Sort By:

Limit search:

THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

100%

Il’ina A. V., Shagdarova B. T., Lunkov A. P., Varlamov V. P.

Progress on Chemistry and Application of Chitin and its Derivatives

2020

vol. 25

5 - 15

This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.

CELL BINDING AND PENETRATION OF QUATERNIZED CHITOSAN DERIVATIVES

100%

Zubareva A. A., Shagdarova B. T., Varlamov V. P., Svirshchevskaya E. V.

Progress on Chemistry and Application of Chitin and its Derivatives

2016

vol. 21

217-223

Chitosan (Ch) is an attractive biopolymer with multiple reactive groups. However it is poorly soluble at neutral pH. Quaternization improves its solubility and permits the development of various positively charged drug delivery systems. The aim of this work was to study the solubility, toxicity, cell binding, and penetration of 20 kDa chitosan with 9, 40, 58 and 98% of quaternary ammonium group substitution (ChQ1 to ChQ4 accordingly). We showed that ChQ with substitution degree >40% was soluble in a wide pH range. Unexpectedly ChQ2 and ChQ3 were more toxic to cells than Ch, ChQ1 and ChQ4. Higher toxicity of ChQ was found against macrophage like cell line RAW264.7 than against epithelial cells MiaPaCa-2. All ChQ, in contrast to unmodified Ch, easily bound and penetrated the cells with the highest uptake by ChQ4. Thus, quaternized chitosan derivatives can be used for biomedical applications.

Refine search results

2 Progress on Chemistry and Application of Chitin and its Derivatives

1 2020

1 2016

2 Shagdarova B. T.

2 Varlamov V. P.

1 Il’ina A. V.

1 Lunkov A. P.

1 Svirshchevskaya E. V.

1 Zubareva A. A.

Search results

THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

CELL BINDING AND PENETRATION OF QUATERNIZED CHITOSAN DERIVATIVES