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The influence of proteasome inhibitor on the expression of cardiomyocytes damage markers after incubation with doxorubicin

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Tereszkiewicz S., Matysiak W., Mandziuk S., Korga A., Oleksiejuk M., Hejna M., Korobowicz-Markiewicz A., Iwan M., Dudka J.
Current Issues in Pharmacy and Medical Sciences
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2014
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vol. 27
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issue 2
88-91
EN
The aim of the study was to verify the thesis that the cardiotoxic effects of doxorubicin are connected with activation of the ubiquitin - proteasome pathway followed by protein degradation. The expression of myocardial damage markers - fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) was evaluated in rat fetal cardiomyocytes simultaneously treated with doxorubicin and the proteasome inhibitor - bortezomib. The level of H-FABP and BNP protein under the influence of doxorubicin was decreased below the detection threshold with unchanged (H-FABP) or elevated (BNP) mRNA expression level. Against the expectations, the inhibitor of proteasome did not abolish this effect. The observed abnormal expression of BNP and H-FABP protein after doxorubicin treatment makes their diagnostic significance in anthracycline cardiotoxicity questionable.
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