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Defense against own arms: staphylococcal cysteine proteases and their inhibitors.

100%

Dubin G.

2003

vol. 50

issue 3

715-724

Staphylococcus aureus is a human pathogen causing a wide range of diseases. Most staphylococcal infections, unlike those caused by other bacteria are not toxigenic and very little is known about their pathogenesis. It has been proposed that a core of secreted proteins common to many infectious strains is responsible for colonization and infection. Among those proteins several proteases are present and over the years many different functions in the infection process have been attributed to them. However, little direct, in vivo data has been presented. Two cysteine proteases, staphopain A (ScpA) and staphopain B (SspB) are important members of this group of enzymes. Recently, two cysteine protease inhibitors, staphostatin A and staphostatin B (ScpB and SspC, respectively) were described in S. aureus shedding new light on the complexity of the processes involving the two proteases. The scope of this review is to summarize current knowledge on the network of staphylococcal cysteine proteases and their inhibitors in view of their possible role as virulence factors.

New generation of peptide antibiotics

84%

Dubin A., Mak P., Dubin G., Rzychon M., Stec-Niemczyk J., Wladyka B., Maziarka K., Chmiel D.

2005

vol. 52

issue 3

633-638

The increasing antibiotic resistance of pathogenic bacteria calls for the development of alternative antimicrobial strategies. Possible approaches include the development of novel, broad-spectrum antibiotics as well as specific targeting of individual bacterial virulence factors. It is impossible to decide currently which strategy will prove more successful in the future since they both promise different advantages, but also introduce diverse problems. Considering both approaches, our laboratory's research focuses on the evaluation of hemocidins, broad-spectrum antibacterial peptides derived from hemoglobin and myoglobin, and staphostatins, specific inhibitors of staphopains - Staphylococcus aureus secreted proteases that are virulence factors regarded as possible targets for therapy. The article summarizes recent advances in both fields of study and presents perspectives for further development and possible applications.

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2 Acta Biochimica Polonica

1 2005

1 2003

2 Dubin G.

1 Chmiel D.

1 Dubin A.

1 Mak P.

1 Maziarka K.

1 Rzychon M.

1 Stec-Niemczyk J.

1 Wladyka B.

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Defense against own arms: staphylococcal cysteine proteases and their inhibitors.

New generation of peptide antibiotics