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Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

100%

Folwarczna J., Nowińska B., Śliwiński L., Pytlik M., Cegieła U., Betka A.

2011

vol. 58

issue 3

313-319

Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.

Остеостимулююча дія полівалентного орального гелю на стан кісткової тканини нижньої щелепи щурів з преднізолоновим пародонтитом

72%

Levitsky A. P., Borysenko A. V., Stolyar V. G.

issue 6

21-30

Osteostimulatory Effect of Polyvalent Oral Gel on the Bone Tissue of the Rats’ Lower Jaw with Prednisolon Periodontitis A. P. Levitsky, A. V. Borysenko, V. G. Stolyar Objective. To determine osteostimulating effect of polyvalent oral gel on the bone when modeling periodontal prednisolon periodontitis. Materials and Methods. We used polyvalent oral gel containing osteovit (calcium citrate, soy isoflavones, zinc sulfate and vitamin D3), propolis tincture, metrogil-dent, chlorhexidine and silica, which was applied to the oral mucosa in applications during two weeks to rats which recieved prednisolon-containing feed. Altogether, 32 rats. As a comparison drug we used mefenat. Results. The reduction of acid phosphatase activity and increase of the mineralizing index, increase and the ratio of calcium content calcium/protein in the bone tissue under the influence of a polyvalent gel was achieved. Conclusion. Proposed gel has osteostimulating effect.

ОСТЕОСТИМУЛИРУЮЩЕЕ ДЕЙСТВИЕ ПОЛИВАЛЕНТНОГО ОРАЛЬНОГО ГЕЛЯ НА СОСТОЯНИЕ КОСТНОЙ ТКАНИ НИЖНЕЙ ЧЕЛЮСТИ КРЫС С ПРЕДНИЗОЛОНОВЫМ ПАРОДОНТИТОМ А. П. Левицкий, А. В. Борисенко, В. Г. Столяр Поливалентный оральный гель (ПОГ), состоящий из остеовита, настойки прополиса, метрогил-дента, хлоргексидина и диоксида кремния, оказывает остеостимулирующее действие на костную ткань пародонта крыс с преднизолоновым пародонтитом: снижает активность кислой фосфатазы, увеличивает соотношение щелочная фосфатаза/кислая фосфатаза и степень минерализации, снижает степень атрофии альвеолярного отростка

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1 Acta Biochimica Polonica

1 Journal of Health Sciences

1 2014

1 2011

1 Betka A.

1 Borysenko A. V.

1 Cegieła U.

1 Folwarczna J.

1 Levitsky A. P.

1 Nowińska B.

1 Pytlik M.

1 Stolyar V. G.

1 Śliwiński L.

Search results

Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

Остеостимулююча дія полівалентного орального гелю на стан кісткової тканини нижньої щелепи щурів з преднізолоновим пародонтитом