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Polymerization of Sickle Cell Disease and Methaeglobin in the Presence of Paracetamol

100%
Ihenetu S. C., Ikpa C. B. C., Igbokwe W. U., Okeke C. J., Ibe F. C.
World News of Natural Sciences
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2022
|
vol. 43
96-107
EN
This study was designed to examine the Level of Polymerization of Sickle Cell Disease and Methaeglobin in the Presence of Paracetamol, the research was carried out using standard procedures. The present study has shown the level of polymerization of sickle cell disease and methaemoglobin in the presence of paracetamol. Within the experimental time of 30-180 seconds, the relative polymerizations range between the following; 70.43 ± 0.87 to 72.10 ± 0.37 at the control (0 mg/dl), at 50 mg/dl, there was an increase from 65.78 ± 0.89 to 69.47±1.00, at 100 mg/dl there was an increase in the polymerization from 68.96 ± 0.99 to 72.33 ±1.02, at 200 mg/dl there was an increase in the polymerization from 65.96 ± 69.26 ± 1.00 and at 500 mg/dl, there was an increase in the polymerization form 66.05 ± 0.98 to 69.42 ± 0.92. This increase in polymerization can be said to be due to the increase in the absorbance of paracetamol. However, the absorbance of the polymerization mixture in the presence of the malarial drug was not significantly different (p < 0.05) from the control sample at the 30 second. The present study showed that the level of polymerization of Hemoglobin S (HbS) molecules was attenuated upon the introduction of the anti-malarial drugs in the polymerizing mixture. The percentage of methaemoglobin increases with the increase in concentration of paracetamol from 2.77 ± 0.05 to 3.30 ± 0.03 starting from 0 mg/dl to 500 mg/dl concentration.
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Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system

88%
Milker R., Czech Z., Wesołowska M.
Polish Journal of Chemical Technology
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2007
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vol. 9
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issue 2
5-9
EN
The present paper discloses a novel photoreactive solvent-free acrylic pressure-sensitive adhesive (PSA) systems, especially suitable for the so much adhesive film applications as the double-sided, single-sided or carrier-free technical tapes, self-adhesive labels, protective films, marking and sign films and wide range of medical products. The novel photoreactive solvent-free pressure-sensitive adhesives contain no volatile organic compounds (residue monomers or organic solvent) and comply with the environment and legislation. The synthesis of this new type of acrylic PSA is conducted in common practice by solvent polymerisation. After the organic solvent are removed, there remains a non-volatile, solvent-free highly viscous material, which can be processed on a hot-melt coating machine at the temperatures of about 100 to 140°C.
3
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Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

75%
Michalska M., Pająk W., Kołodziejska J., Łazarenkow A., Nawrot-Modranka J.
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2008
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vol. 55
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issue 3
613-617
EN
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
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