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Human diadenosine triphosphate hydrolase: Preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

100%

Asensio A. C., Rodríguez-Ferrer C. R., Oaknin S., Rotllán P.

2000

vol. 47

issue 2

435-441

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.

Adenosine diphosphate receptors on blood platelets - potential new targets for antiplatelet therapy

86%

Rozalski M., Nocun M., Watala C.

2005

vol. 52

issue 2

411-415

Platelets play a key role not only in physiological haemostasis, but also under pathological conditions such as thrombosis. Platelet activation may be initiated by a variety of agonists including thrombin, collagen, thromboxane or adenosine diphosphate (ADP). Although ADP is regarded as a weak agonist of blood platelets, it remains an important mediator of platelet activation evoked by other agonists, which induce massive ADP release from dense granules, where it occurs in molar concentrations. Thus, ADP action underlies a positive feedback that facilitates further platelet aggregation and leads to platelet plug formation. Additionally, ADP acts synergistically to other, even weak, agonists such as serotonin, adrenaline or chemokines. Blood platelets express two types of P2Y ADP receptors: P2Y_1 and P2Y_12. ADP-dependent platelet aggregation is initiated by the P2Y1 receptor, whereas P2Y_12 receptor augments the activating signal and promotes platelet release reaction. Stimulation of P2Y_12 is also essential for ADP-mediated complete activation of GPIIb-IIIa and GPIa-IIa, and further stabilization of platelet aggregates. The crucial role in blood platelet biology makes P2_Y12 an ideal candidate for pharmacological approaches for anti-platelet therapy.

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2 Acta Biochimica Polonica

1 2005

1 2000

1 Asensio A. C.

1 Nocun M.

1 Oaknin S.

1 Rodríguez-Ferrer C. R.

1 Rotllán P.

1 Rozalski M.

1 Watala C.

Search results

Human diadenosine triphosphate hydrolase: Preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

Adenosine diphosphate receptors on blood platelets - potential new targets for antiplatelet therapy