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A Second Relapse of a Solid Pseudopapillary Tumor of the Pancreas: Case Description

100%

Murawa D., Zasadowski Z., Kruszyna Ł.

Polish Journal of Surgery

2008

vol. 80

issue 1

46-50

Solid pseudopapillary tumor (SPT) is a rare pancreatic neoplasm of unspecified origin that occurs most frequently in young women. In most patients, it has a benign character.In study presented a description of the case of a 36-year-old patient operated due to SPT in 2004. The patient had an atypical clinical course of the disease with a double relapse of the neoplastic process, which was operated on in 2006 and 2007.The symptoms and clinical course of SPT are characterized by very high interpersonal variation. Therefore, it is necessary to deepen the knowledge of the histogenesis and biology of the tumor. Additionally, the patients who receive surgery due to the tumor must be observed for many years.

Elevated preoperative levels of CA 19-9 and CA 125 predicts overall survival time in the pancreatic adenocarcinoma. Single institution series.

80%

Hogendorf P., Skulimowski A., Durczyński A., Kumor A., Poznańska G., Poznańska A., Oleśna A., Rut J., Øvereng Juliebø S., Szmiel A., Pirowski W., Strzelczyk J.

Polish Journal of Surgery

2020

vol. 92(3)

32-38

Introduction: Pancreatic cancer is a devastating disease, being the seventh cause of cancer-related deaths worldwide. Its aggressiveness is due to its specific biology and the late diagnosis of cancer. Therefore, the prognosis for patients suffering from this cancer is dismal, with 5-year overall survival rate of around 6–10%. Up to date, only a complete surgical resection of the cancerous entity warrants a significant improvement in patients’ survival. Nevertheless, the pancreatic cancer’s biology is still not fully elucidated, so that the accuracy of prognosis for certain patients is highly uncertain. Consequently, the importance of both clinical and basic research aiming to reveal the crucial molecular factors affecting long-term prognosis should be highlighted. There is a growing number of evidence that biomarkers of PC not only reflect the presence of tumor itself but also present a “hint” regarding its physiology. Thus the aim of this study was to assess the levels of commonly measured biomarkers and their influence on patients’ overall survival. Materials and methods: The retrospective analysis of data on 129 patients admitted to our Department due to the diagnosis of pancreatic cancer was carried out. On the day of admission all the patients had their levels of CA19-9, CA125, CEA and CA15-3 measured. The overall survival (OS) was defined as time elapsing from the day of admission to the day of death. The Kaplan- Meier curves were built for all potential factors, Cox regression model was applied to carry out a multivariate analysis. Results: We retrospectively analyzed 129 patients with a mean age of 62 years. As many as 95 of them had an unresectable lesion and 34 underwent curative operation. In total, the analyzed patient group was characterized by a median survival of 7 months and 12 days. Cumulative 1-year, 2-year and 4-year survival rates were 35%, 16% and 15%, respectively. In univariate analysis, factors such as age >= 60, inoperable lesion, CA19-9 >= 200, CA125 >= 20 and Neutrophile to Lymphocyte Ratio (NLR) >= 5 were associated with a lower median OS. In multivariate analysis, three factors, CA19-9 >= 200, CA125 >= 20 and age >= 60, were found to be statistically significant. Indeed, patients possessing all of them noted much poorer outcomes regarding OS factors: 89 days versus 235 days for the other patients (log rank test P = 0.02). Conclusions: Our study fortifies the evidence that preoperative levels of CA19-9 and CA125 have a direct influence on the longterm OS. Interestingly, in our patient group, the correlation of biomarkers with OS was higher than that of resectability. However, our study has some limitations regarding, for instance, the lack of data on chemotherapy, comorbidities etc. In the view of recent molecular studies on mucin involvement in PC development, it provides a strong clinical evidence to prove their importance.

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2 Polish Journal of Surgery

1 2020

1 2008

1 Durczyński A.

1 Hogendorf P.

1 Kruszyna Ł.

1 Kumor A.

1 Murawa D.

1 Oleśna A.

1 Pirowski W.

1 Poznańska A.

1 Poznańska G.

1 Rut J.

1 Skulimowski A.

1 Strzelczyk J.

1 Szmiel A.

1 Zasadowski Z.

1 Øvereng Juliebø S.

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A Second Relapse of a Solid Pseudopapillary Tumor of the Pancreas: Case Description

Elevated preoperative levels of CA 19-9 and CA 125 predicts overall survival time in the pancreatic adenocarcinoma. Single institution series.