Tapentadol is the newest opioid with dual mechanism of action, that gives the potential to spare some opioid-induced adverse events. Studies involving this drug in acute pain are not numerous. The aim of this study was to compare the efficacy and tolerance of tapentadol and oxycodone in patients after abdominal hysterectomy. Patients were randomly allocated into two groups receiving: I. tapentadol (50 mg) and II. oxycodone (10 mg), every 12 hours postoperatively. The Numerical Rating Scores (NRS), vital signs, main adverse events (postoperative nausea and vomiting, sedation) and other side effects would be recorded until discharge. Total opioid consumption, the patients’ satisfaction, adjuvants consumption, and length of hospital stay were also assessed Mean NRS scores for tapentadol and oxycodone after 24, 48 and 72 hours were: 3.43 (±1.29) vs 3.59 (±1.37), 2.87 (±1.07) vs 3.24 (±1.21), 2.80 (±1.05) vs 3.19 (±1.24), respectively. In the tapentadol group, superior pain control (p<0.05) in few time points during the day second was observed although demand for rescue analgesics was slightly higher (p>0.05). Mucosal dryness affected over >90% patients in both groups. The incidence of postoperative nausea was 39.5% (tapentadol) and 27% (oxycodone) on the first day. The incidence of drowsiness was 42.1% (tapentadol) and 37.8% (oxycodone). Other adverse events’ level, satisfaction with treatment, length of stay after surgery, effect on vital signs were comparable.
Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side eefcts. Patients who use oxycodone may have one or more side eefcts depending on their clinical status and/or other factors. Our aim was to analyze clinical trials for any potential paetrn related to the side eefcts of oxycodone. Methods: We searched the ClinicalTrials.gov database for clinical studies conducted around the world regarding oxycodone. A number of general data analytic and text manipulation techniques were used in the Python programming language. Results: We analyzed 842 clinical trials involving oxycodone. Our results suggest that the researchers focused on oxycodone's typical side eefcts (e.g. vomiting), as opposed to the less evident and/or long-term side eefcts e.g. depression, confusion and constipation. Conclusions: The adverse eefcts of oxycodone most commonly reported in the clinical trials are nausea, vomiting and depression. Despite the clinical use of oxycodone in all the age groups (including infants), very few of the publicly-available clinical trials included participants < 18 years of age. Toussi AG, Toosi FG. A quantitative analytical investigation on the oxycodone side eefcts listed in recent clinical trials. Eur J Transl Clin Med. 2023;6(1):58-63.
Treatment of postoperative pain is an extremely important aspect in surgical treatment and may affect the assumed results. In the case of patients after high tibial opening wedge osteotomy pharmacotherapy of patinents‘ pain, in the early postoperative stage, is as important as the assumed and operationally gained degree of axis correction. Application of efficient and well-tolerated opioid, oxycodone hydrochloride, in the anti-pain treatment contributes to faster patient’s activity, which in turn lowers number of complications connected with such procedures.
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Leczenie bólu pooperacyjnego jest niezmiernie istotnym elementem leczenia chirurgicznego i może przekładać się na uzyskane efekty. W przypadku wysokiej dewaryzującej osteotomii podkolanowej farmakoterapia bólu u pacjentów jest we wczesnym okresie pooperacyjnym równie istotna jak zakładany i uzyskany operacyjnie stopień korekcji osi. Wykorzystanie skutecznego i dobrze tolerowanego opioidu jakim jest chlorowodorek oksykodonu w postępowaniu przeciwbólowym przyczynia się do zwiększenia satysfakcji z leczenia i szybkiego uruchomienia pacjenta, co z kolei zmniejsza liczbę powikłań związanych z tego typu procedurą.
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