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  1. 2 Acta Physica Polonica A

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  1. 2 2018

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  1. 2 Cicek M.

  2. 2 Dede B.

  3. 2 Gorgulu G.

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Synthesis and Characterization of a Novel Aminoketooxime Ligand and Enzymatic Efficiencies of Its Metal Complexes

100%
Gorgulu G., Cicek M., Dede B.
Acta Physica Polonica A
|
2018
|
vol. 133
|
issue 2
244-249
EN
A novel aminoketooxime ligand and its mononuclear Cu(II) and Mn(II) complexes were synthesized. The structures of the synthesized compounds were illuminated by elemental analysis, inductively coupled plasma optical emission spectrometry, the Fourier transform infrared, ¹H- and ¹³C-NMR, UV-Vis, magnetic susceptibility and conductivity measurements. According to the characterization studies ligand to metal ratio was found to be 2:1 with strong binding affinity of the ligand to the metal ions. In addition, complexes have been tested for their catecholase and phenoxazinone synthase-like activities. Kinetic studies were also carried out yielding V_{max}, k_{cat} and K_{M} values of both complexes for catecholase and phenoxazinone synthase-like activities. Both complexes efficiently catalyzed the reactions of the enzymes they mimicked.
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Novel Aminoketooxime Ligand and Its Cu(II) and Mn(II) Complexes: Synthesis, Characterization and Molecular Docking Studies

86%
Gorgulu G., Cicek M., Dede B.
Acta Physica Polonica A
|
2018
|
vol. 133
|
issue 2
250-255
EN
A novel ligand, N,N"-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H₂L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by ¹H- and ¹³C-NMR, the Fourier transform infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2.
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