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Generating Organic Compounds by Retrosynthetic Pathway via Typical Corey’s Synthesis

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Ononiwu C. G., Enwereuzo O. O., Akakuru O. C., Ejiogu C. B., Onumah C. U., Achukee C. K., Umaefulam T. N., Abaekwume N. N., Akakuru O. U.

World News of Natural Sciences

2021

vol. 36

88-98

Several methods exist for the synthesis of alkanes including Corey’s synthesis, Wurtz reaction, reduction of alcohols and aldehydes, Kolbe’s electrolysis, hydrogenation of alkenes, and Grignard reaction. Among the available methods, the age-long Corey’s synthesis presents robust advantages of yielding symmetrical, unsymmetrical, straight chain and branched chain alkanes. Moreover, it allows of generating high yields of alkanes by utilizing primary alkyl halide and an array of lithium dialkyl copper ranging from primary, secondary to tertiary. Corey’s synthesis has also been implicated in the synthesis of various organic compounds such as (+)-taylorione, terminal alkynes, caribenol A, ketones, and aldehydes. In this work, an explanation of the general concept in the Corey’s synthesis is provided. Furthermore, specific examples of Corey’s reactions and modifications are discussed. Finally, an outlook into the benefits of the Corey’s synthesis in present-day organic synthesis is provided, which is expected to enhance the understanding of organic reaction mechanisms for the development of various organic compounds as drugs for treating diseases.

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1 World News of Natural Sciences

1 2021

1 Abaekwume N. N.

1 Achukee C. K.

1 Akakuru O. C.

1 Akakuru O. U.

1 Ejiogu C. B.

1 Enwereuzo O. O.

1 Ononiwu C. G.

1 Onumah C. U.

1 Umaefulam T. N.

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Generating Organic Compounds by Retrosynthetic Pathway via Typical Corey’s Synthesis