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Wpływ melatoniny na czynność układu sercowo-naczyniowego

100%

Sewerynek E.

Folia Medica Lodziensia

2010

vol. 37

issue 1

69-87

The ageing process is associated with an increasing number of cardiovascular incidents, both acute and chronic. Also the concentrations of certain hormones undergo a gradual decrease with age, including: oestrogens, androgens, dehydroepiandrosterone, dehydroapiandrosterone sulphate or melatonin. The association between melatonin and circulation has been the subject of interest for the last few years. It has also been demonstrated that the vasospastic or vasodilative effects of melatonin depend on the activation of certain receptors by the hormone. Cardioprotective effects of melatonin have been demonstrated in both experimental and clinical studies. In cardiac ischemia-reperfusion models or in the course of oxidative process induction, following the administration of medical agents with cardiotoxic effects, protective effects of melatonin have been demonstrated. In patients with ischaemic heart disease, lower nocturnal melatonin concentrations were found vs. those in a group of healthy persons; the more severe cardiac disease and the higher risk for sudden cardiac death, the lower melatonin concentrations are observed. Lower melatonin concentrations have also been confirmed in patients with hypercholesteronaemia and increased LDL-cholesterol fraction levels, as well as in patients with arterial hypertension. Melatonin administration normalised blood pressure in patients with arterial hypertension. The presented paper aims at summarising the up-to-date knowledge of the role of melatonin in circulation control.

melatonin. The association between melatonin and circulation has been the subject of interest for the last few years. It has also been demonstrated that the vasospastic or vasodilative effects of melatonin depend on the activation of certain receptors by the hormone. Cardioprotective effects of melatonin have been demonstrated in both experimental and clinical studies. In cardiac ischemia-reperfusion models or in the course of oxidative process induction, following the administration of medical agents with cardiotoxic effects, protective effects of melatonin have been demonstrated. In patients with ischaemic heart disease, lower nocturnal melatonin concentrations were found vs. those in a group of healthy persons; the more severe cardiac disease and the higher risk for sudden cardiac death, the lower melatonin concentrations are observed. Lower melatonin concentrations have also been confirmed in patients with hypercholesteronaemia and increased LDL-cholesterol fraction levels, as well as in patients with arterial hypertension. Melatonin administration normalised blood pressure in patients with arterial hypertension. The presented paper aims at summarising the up-to-date knowledge of the role of melatonin in circulation control.

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1 Folia Medica Lodziensia

1 2010

1 Sewerynek E.

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Wpływ melatoniny na czynność układu sercowo-naczyniowego