Search results

Search:
in the keywords: neoplasia

Sort By:

Limit search:

An unusual presentation of corneal intraepithelial neoplasia

100%

Marticorena-Álvarez P., Garrido Ceca G., Celdrán Vivancos D. A.

OphthaTherapy

2020

vol. 7

issue 4

302-304

Introduction: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion. Clinical case: An 80-year-old woman with an elevated, avascular, well-demarcated grey corneal plaque. After epitheliectomy and alcohol, the excised lesion was identified as a high-grade epithelial neoplasia. Treatment was topical interferon α-2b for 1 month without recurrences. Conclusions: A well-defined greyish corneal opacity should always raise suspicion of an intraepithelial neoplasia. In the present case, epitheliectomy and topical recombinant interferon proved successful.

On the relationship between fractal geometry of space and time in which a system of interacting cells exists and dynamics of gene expression.

100%

Waliszewski P., Molski M., Konarski J.

2001

vol. 48

issue 1

209-220

We report that both space and time, in which a system of interacting cells exists, possess fractal structure. Each single cell of the system can restore the hierarchical organization and dynamic features of the entire tumor. There is a relationship between dynamics of gene expression and connectivity (i.e., interconnectedness which denotes the existence of complex, dynamic relationships in a population of cells leading to the emergence of global features in the system that would never appear in a single cell existing out of the system). Fractal structure emerges owing to non-bijectivity of dynamic cellular network of genes and their regulatory elements. It disappears during tumor progression. This latter state is characterized by damped dynamics of gene expression, loss of connectivity, loss of collectivity (i.e., capability of the interconnected cells to interact in a common mode), and metastatic phenotype. Fractal structure of both space and time is necessary for a cellular system to self-organize. Our findings indicate that results of molecular studies on gene expression should be interpreted in terms of space-time geometry of the cellular system. In particular, the dynamics of gene expression in cancer cells existing in a malignant tumor is not identical with the dynamics of gene expression in the same cells cultured in the monolayer system.

Refine search results

1 Acta Biochimica Polonica

1 OphthaTherapy

1 2020

1 2001

1 Celdrán Vivancos D. A.

1 Garrido Ceca G.

1 Konarski J.

1 Marticorena-Álvarez P.

1 Molski M.

1 Waliszewski P.

Search results

An unusual presentation of corneal intraepithelial neoplasia

On the relationship between fractal geometry of space and time in which a system of interacting cells exists and dynamics of gene expression.