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1
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Tissue remodelling in chronic rhinosinusitis – review of literature

100%
Radajewski K., Wierzchowska M., Grzanka D., Antosik P., Zdrenka M., Burduk P.
Otolaryngologia Polska
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2019
|
vol. 73(5)
1-4
EN
CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.
2
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Tissue remodelling in chronic rhinosinusitis – review of literature

100%
Radajewski K., Wierzchowska M., Grzanka D., Antosik P., Zdrenka M., Burduk P.
Polish Journal of Otolaryngology
|
2019
|
vol. 73
|
issue 5
1-4
EN
CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.
3
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Influence of vitamin D3 analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts

75%
Rostkowska-Nadolska B., Frączek M., Gawron W., Latocha M.
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|
issue 2
235-242
EN
Vitamin D (VD) and its different analogues, besides their classic role as regulators of calcium and phosphor homeostasis, have emerged as a large family of antiproliferative agents. Such properties suggested VD potential as a therapy for chronic inflammatory diseases, including nasal polyposis (NP). NP growth involves both an inflammatory process and the proliferation of fibroblast as an important factor inducing aberrations in the phenotype of the epithelium. The aim of this study was to investigate the possible influence of 1α,25-dihydroxyvitamin D3 (calcitriol) and 1α,24(R)-dihydroxyvitamin D3 (tacalcitol) in monotherapy and in combination with budesonid R (BR) on NP fibroblast proliferation. Material and methods: The study involved 26 samples of NP. NP cells were cultured on 96-well plates beginning with a concentration of 5 × 103 cells per well with RPMI 1640 medium supplemented with antibiotics and 10% foetal bovine serum. After the fourth to sixth passage the medium was replaced with a nutrient medium with calcitriol or tacalcitol in a defined concentration (from 10-9 M to 10-3 M) alone or in combination with BR in 1:1, 1:3 or 3:1 ratios, each at concentrations from 10-5 M to 10-3 M. Results: Growth inhibition of nasal fibroblasts exposed to calcitriol or tacalcitol was noted. Significant antiproliferating activity was observed at calcitriol concentrations of 10-4 M and 10-3 M after 48 h, and at a concentration of 10-3 M after 72 h with the percentage of proliferating cells reduced to 30% compared to the control samples (P < 0.05). In cells treated with tacalcitol the maximal effect was seen at 10-4 M after 48 h and at 10-3M after 72 h with a 60% inhibition with respect to the control (P < 0.05). The inhibition of fibroblast proliferation reached the maximal level when they were exposed to calcitriol: BR (1 : 1) or tacalcitol: BR (1 : 1), each at a concentration of 10-4 M, after 72 h (82% and 69%, respectively). Conclusions: The antiproliferative activity of calcitriol and tacalcitol in NP cultures was confirmed. Because of its lower toxicity and higher activity tacalcitol seems to be the more promising agent in NP therapy, both as a single medication and in treatment protocols with BR.
4
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Rola interleukiny-5 i eotaksyny-2 w powstawaniu nacieków eozynofilowych w tkance polipów nosa

63%
Iwańska J., Czecior E., Mrówka-Kata K., Wolny A.
Annales Academiae Medicae Silesiensis
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2009
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vol. 63
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issue 6
69-74
EN
The paper presents the problem of etiopathogenesis of nasal polyps, presentation the role of eosinophilic infi ltration in nasal polyps genesis as well as description of the current partition of them. The paper also presents the discussion on the role of polyps’ factor creation, which causes the increase of infl ammatory cells proliferation – interleukin-5 as well as stimulation of their chemotaxis–eotaxin-2.
PL
W pracy przedstawiono problem etiopatogenezy polipów błony śluzowej nosa. Przedstawiono rolę nacieków eozynofilowych w ich genezie oraz zaprezentowano obecnie obowiązujący ich podział. Omówiono znaczenie w powstawaniu polipów nosa czynnika wzmagającego proliferację komórek zapalnych – interleukiny-5 oraz pobudzającego ich chemotaksję – eotaksyny-2.
5
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EPOS2020: What’s new for physician practitioners?

63%
Arcimowicz M., Niemczyk K.
Polski Przegląd Otorynolaryngologiczny
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2020
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vol. 9(2)
7-17
EN
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 also abbreviated to EPOS2020, is the new edition of the European document devoted to the broadly understood topic of inflammation of the nasal mucosa and paranasal sinuses. The first edition appeared in 2005, followed by further editions in 2007 and 2012. In February 2020, we received the latest version, extended, somewhat modified, expanded to include the latest research and meta-analysis in the fields of: rhinology, rhinosurgery, epidemiology and reports on comorbidities. A completely new division of chronic sinusitis was presented. Recommendations based on the highest quality evaluations, resulting from the publication of the last eight years, also introduce a system based on integrated care pathways, or ICP in sinusitis. Chapters on pediatric aspects and sinus surgery have been expanded. EPOS2020 is addressed not only to doctors, but also to: nurses, pharmacists, other healthcare workers, as well as patients themselves, who often make the first attempts at treatment with OTC preparations, frequently based on the recommendations of pharmacists. The latest EPOS also specifies directions for further lines of research in the broadly understood field of rhinosinusitis.
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