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Copper(II) complexes of the antihypertensive drug nadolol

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Getova V., Pantcheva I., Ivanov D., Mehandjiev D., Skumryev V., Bontchev P.

Open Chemistry

2007

vol. 5

issue 1

118-131

The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to formation of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL2·2Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2·H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. [...]

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1 Open Chemistry

1 2007

1 Bontchev P.

1 Getova V.

1 Ivanov D.

1 Mehandjiev D.

1 Pantcheva I.

1 Skumryev V.

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Copper(II) complexes of the antihypertensive drug nadolol