Search results

Search:
in the keywords: myocardial damage

Sort By:

Limit search:

THE PREVENTIVE EFFECTS OF RUTIN ON IMMOBILIZATION STRESS-INDUCED CARDIAC DAMAGE IN RATS

100%

Coskun R., Inan A., Suleyman Z., Cimen F. K., Cankaya M.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 6

1079-1087

Background: The previous studies formed the role of oxidants and proinflammatory cytokines in the pathogenesis of acute psychological stress-related cardiac damage leading to mortality and other complications. The aim of the study is to examine the protective effect of rutin against stress-induced cardiac damage. In the literature, no studies have been found analyzing the effects of rutin in acute stress related oxidative damage induced by immobilization method in rats.Material and Methods: Rutin was administered orally to rutin + stress applied (RSG) group albino rats at a dose of 50 mg/kg. For healthy control (HG) and stress applied to control (SAG) groups, distilled water as a solvent was orally administered at the same volume (0.5 ml). One hour after rutin and distilled water applications, all animals except for HG brought into supine position and their legs and arms were ligated and kept in the same position for 24 hours.Results: Oxidant, cytokine and cardiac biomarker levels in blood serum and heart tissues of SAG animals were found to be significantly higher and total glutathione was lower than RSG and HG groups. Histopathologically dilated conjugated blood vessels and myocardial destruction, hemorrhage, edema, and polymorphonuclear leucocyte infiltration were observed in the SAG heart tissues. On the other hand, the histological heart tissue results of the RSG group was found to be similar compare to healthy tissue except for the slightly dilated conjugated blood vessel. Conclusion: These results indicate that the rutin may be useful in the treatment of stress-related oxidative cardiac damage

QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE- INDUCED CARDIOTOXICITY

100%

Kushwah A. S., KALIA T. S.

Acta Poloniae Pharmaceutica - Drug Research

2020

vol. 77

issue 2

343-352

Acrylamide (ACR) is a foodborne toxic agent, formed in food when processed at high temperature. This study aimed at evaluating the biochemical changes induced by ACR and the effect of Quercetin as a treatment against ACR induced cardiotoxicity in rats. Wistar rats of either sex (n=6) were divided into four groups as follows: normal control, an Acrylamide control group, Quercetin groups (25 and 50 mg/kg). Diagnostics characteristics were assessed daily, at the end of the study (4 weeks) evaluate hemodynamic parameters, the blood sample was collect for estimation of biochemical and rats were decapitated excised hearts, cleaned and weighed. Heart homogenate was used to determine antioxidants and oxidative levels, and histopathological evaluations were carried out to determine changes induced by Acrylamide. As compared control groups, ACR treated rats show altered significantly (P < 0.05) general characteristic and also elevated myocardial damage markers, altered hemodynamic, oxidative stress level, increased expression of inflammatory cytokines and induced histopathological changes. Treatment with Quercetin at 25 mg/kg and 50 mg/kg recouped the above changes significantly (P < 0.05), 50 mg/kg being more prominent. The present study has concluded that Quercetin protects against Acrylamide-induced cardiotoxicity.

Refine search results

2 Acta Poloniae Pharmaceutica - Drug Research

1 2020

1 2019

1 Cankaya M.

1 Cimen F. K.

1 Coskun R.

1 Inan A.

1 KALIA T. S.

1 Kushwah A. S.

1 Suleyman Z.

Search results

THE PREVENTIVE EFFECTS OF RUTIN ON IMMOBILIZATION STRESS-INDUCED CARDIAC DAMAGE IN RATS

QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE- INDUCED CARDIOTOXICITY