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Cytotoxic effect of nitric oxide on human hematological malignant cells.

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Tsumori M., Tanaka J., Koshimura K., Kawaguchi M., Murakami Y., Kato Y.

2002

vol. 49

issue 1

139-144

We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.

Plasma cell myeloma as one of the causes of bone pain in family medicine

100%

Kade G., Michalak M., Kade B., Spaleniak S., Podgórska A., Hałka J.

OncoReview

2023

vol. 13

issue 1

33-35

The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.

Patient with atypical chest pain and nephrotic range proteinuria finally diagnosed with non-secretory myeloma

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Holecki M., Fryźlewicz-Moska A., Strzałkowska D., Chudek J., Duława J.

Annales Academiae Medicae Silesiensis

2010

vol. 64

issue 5-6

89-91

Multiple myeloma is the second most common neoplastic disease of lymphoid tissue in adults. However, its atypical non secretory form, is quite rare. We present a case of 70 year old male with atypical chest pain and nephrotic range proteinuria fi nally diagnosed as non secretory myeloma who did not present any of characteristic fi ndings when admitted to hospital. Despite the unusual course the diagnosis was established quickly enough to provide a proper treatment. One should remember that occasionally patients do not match typical criteria necessary for diagnosing a disease.

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1 Acta Biochimica Polonica

1 Annales Academiae Medicae Silesiensis

1 OncoReview

1 2023

1 2010

1 2002

1 Chudek J.

1 Duława J.

1 Fryźlewicz-Moska A.

1 Hałka J.

1 Holecki M.

1 Kade B.

1 Kade G.

1 Kato Y.

1 Kawaguchi M.

1 Koshimura K.

1 Michalak M.

1 Murakami Y.

1 Podgórska A.

1 Spaleniak S.

1 Strzałkowska D.

1 Tanaka J.

1 Tsumori M.

Search results

Cytotoxic effect of nitric oxide on human hematological malignant cells.

Plasma cell myeloma as one of the causes of bone pain in family medicine

Patient with atypical chest pain and nephrotic range proteinuria finally diagnosed with non-secretory myeloma