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NEUROPHARMACOLOGICAL EVALUATION OF SEDATIVE AND MUSCLE RELAXANT PROPERTIES OF RAPHANUS CAUDATUS IN ALBINO MICE

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younus i., siddiq a., sadaf r.
Acta Poloniae Pharmaceutica - Drug Research
|
2019
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vol. 76
|
issue 5
855-862
EN
Objectives In present days vegetables and fruits provided by nature are underutilized and underestimated. Raphanus caudatus, is one of an ignored vegetable belonging to radish plant because it is not only underutilized by the population but also the researches had not focused to identify its phytochemistry as well as pharmacological potential. The present study was designed with the aim to evaluate bioactive principles along with sedative and muscle relaxant properties of ethanol extract of Raphanus caudatus in mouse model. Methodology In the current study effects of ethanol extract of Raphanus caudatus were observed on general performance and behavioral changes of mice. Moreover sedative and muscle relaxant properties of extract was evaluated at three different doses (250, 500 and 1000 mg/kg) in mouse model using phenobarbitone induced sleeping time and rota rod test respectively. Result The ethanol extract of Raphanus caudatus indicated the occurrence of carbohydrates, flavonoids, alkaloids, terpenoids as well as tannins. The extract at highest tested doses i.e. 1000 mg/kg produced significant (p<0.05) sedative action. However, the extract was found to be lacking in muscle relaxant properties at any of tested dose in mice up to 60 days post treatment. Conclusion The study shows that ethanol extract of Raphanus caudatus possess sedative neuro-pharmacological potential and may possibly be used as valuable source of bioactive constituents with psychosedative properties.
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