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1

The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

100%

Drobiecki A., Pasiarski M., Stelmach-Gołdyś A., Garus B.

OncoReview

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2017

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vol. 7

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issue 4

180-183

EN

Cutaneous and soft tissue involvement is a very rare manifestation of multiple myeloma. We are describing a woman with the huge multiple plasma cells infiltrations of the soft tissues and the skin of the right shoulder and the arm that had occurred 2.5 years after the diagnosis of multiple myeloma. In the case of the described patient there is a distinct correlation between the appearance of the nodular lesions in soft tissues and the underlying osteolytic changes found in the skeleton. We assumed that the fracture of the right humerus in the past was the beginning of the plasma cells dissemination in the adherent tissues. The skin changes in our patient appeared in the advanced stage of multiple myeloma. There was only transient improvement of cutaneous changes after the chemotherapy, despite the complete remission of the underlying disease in the bone marrow. Despite of the intensive treatment (chemotherapy, radiotherapy) the patient died 7 months after the first appearance of the skin changes.

2

IgM multiple myeloma: diagnostic difficulties and results of bortezomib treatment – case report

80%

Machowicz R., Skwierawska K., Mądry K., Górka M., Żurawska J., Kacprzyk P., Waszczuk-Gajda A., Dwilewicz-Trojaczek J.

OncoReview

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2014

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vol. 4

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issue 4

A160-A164

EN

The IgM paraprotein secretion is most frequently associated with Waldenström’s macroglobulinemia. In very rare cases it may also occur in multiple myeloma. The diagnostic and therapeutic process of a 84 year old male suffering from IgM multiple myeloma is described, including difficulties in establishing this diagnosis. Due to infectious complications, after the first cycle of melphalan– prednisone–bortezomib treatment, melphalan was stopped, subsequently, bortezomib and prednisone doses were also reduced. Two treatment interruptions have occurred. Despite reduced treatment intensity, the patient was in very good partial remission, while the toxicity profile was acceptable. IgM multiple myeloma should be included in the differential diagnosis of IgM paraproteinemia, also when osteolytic lesions and translocation 11:14 are not detected. Bortezomib-based therapy can be effective in elderly patients (also in those suffering from cardiac insufficiency), even when dose reduction is required.

3

Comparison of the free and total light chain assays in serum and urine samples with immunofixation electrophoresis for detecting monoclonal proteins in patients with monoclonal gammopathy

70%

Korpysz M., Morawska M., Burska A., Donica H.

Current Issues in Pharmacy and Medical Sciences

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2014

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vol. 27

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issue 3

165-170

EN

Monoclonal protein (M-protein) is produced by a malignant clone of plasma cells. Detected in serum and/or urine, this typically indicates multiple myeloma (MM) or other monoclonal gammopathy (MG). In a majority of MM cases, with the production of intact monoclonal immunoglobulin (Ig), malignant plasmocytes and/or B lymphocytes often produce excessive amounts of free light chains (FLCs). Excessive synthesis of FLCs lowers the ability of renal proximal tubules to re-absorb FLCs, which results in abnormally high levels of FLCs in the urine (Bence Jones protein, BJP). In laboratory practice, there are tests available for the quantitative measurement of only FLCs κ and λ or for total light chains (TLCs). These tests measure both free forms and bound in the (Ig) molecules forms as light chains that are evident in the serum and in urine. The purpose of this study was to evaluate the FLCs and TLCs approaches in screening serum and urine samples of patients with MM, doing so in comparison to the results of immunofixation (IFE) assessment. A second purpose was to assess the suitability of the collected material for obtaining the most reliable results. The results of serum FLCs (sFLCs) assays suggest that this approach is of the highest reliability and diagnostic usefulness in the detection of MG with excess production of FLCs, in comparison to other available tests. In our work, when κ band light chains were detected in serum IFE (sIFE), 91% patients had their FLCs concentrations beyond the reference range, whereas 89% patients had increased λ FLCs when λ band light chains were detected in sIFE. We also found abnormal sFLC κ/λ ratios in 86.4% and 88.9% of all subject patients who had κ or λ band light chains detected in their sIFE, respectively.

4

Advances in hematology – research that revolutionized patient care

51%

Wach M., Podhorecka M., Cioch M., Hus I., Wąsik-Szczepanek E., Sokołowska B., Hus M.

Polish Journal of Public Health

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2015

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vol. 125

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issue 1

32-35

EN

In the last decades, substantial strides have been made in the diagnosis, treatment, and prevention of blood diseases. The new drugs to be used in combination with cytostatic therapy have been developed, based on increased understanding of the biology of neoplasia. The diagnosis of several diseases is based exclusively on cytogenetic and molecular analysis which has become a part of routine diagnostic management. Moreover, molecular definition has allowed the introduction of therapy targeted at molecular change characteristic for a given disease. The introduction of novel agents for the treatment of hematological disorders has resulted in a great improvement in response rate and median survival. The aim of this study is to show advances and possible future directions in the treatment of chosen hematological malignancies during the recent decades.

5

Opieka pielęgniarska nad pacjentem ze szpiczakiem mnogim, po autologicznym przeszczepieniu krwiotwórczych komórek macierzystych – studium przypadku.

51%

Kurek M. S., Tatara T., Patyk A.

Long-Term Care Nursing

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2020

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vol. 5

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issue 2

147-157

EN

Introduction Multiple myeloma is one of the most common haematological cancer among adults. The main symptom of multiple myeloma is bone pain because of osteolysis, usually confused with osteoporosis. The basis method of treatment is chemotherapy with autologous hematopoietic stem cell transplantation. Aim The purpose of the work is case study of patient with diagnosed multiple myeloma and presentation of patient problems and nursing interventions in peri-transplant period Material and methods Information was collected by observation, interview and analysis of medical documentation of patient. Presented case show a 53 years old women, with multiple myeloma, who was treated by chemotherapy with autologous hematopoietic stem cell transplantation. Results One of the potential factors, which influence on development of cancer is lack of appropriate amount of dream, but in the literature we can find controversial information. Using ICNP® in practice, makes easier work of nurses. Conclusions Patients nursing care after autologous hematopoietic stem cell transplantation is difficult. As a result of treatment side effects, patients have a lot of problems. They require professional care and support.

PL

Wstęp Szpiczak mnogi (ang. multiple myeloma) stanowi jeden z najczęściej występujących nowotworów hematologicznych wśród dorosłych. Głównym objawem szpiczaka jest ból kości spowodowany osteolizą, zazwyczaj mylony z osteoporozą. Podstawową metodą leczenia jest chemioterapia wraz z autologicznym przeszczepieniem krwiotwórczych komórek macierzystych. Cel Celem pracy jest analiza przypadku pacjentki ze zdiagnozowanym szpiczakiem mnogim oraz przedstawienie problemów chorej i postępowania pielęgniarskiego w okresie okołotransplantacyjnym. Materiał i metody Informacje zebrano poprzez obserwację, wywiad i analizę dokumentacji medycznej pacjentki. Prezentowany przypadek opisuje kobietę w wieku 53 lat, ze szpiczakiem plazmocytowym, poddanej chemioterapii z autoprzeszczepieniem krwiotwórczych komórek macierzystych. Wyniki Jednym z potencjalnych czynników wpływających na rozwój nowotworu jest brak odpowiedniej ilości snu, jednak literaturze można odnaleźć kontrowersyjne informacje. Wnioski Opieka pielęgniarska nad pacjentem po autotransplantacji krwiotwórczych komórek macierzystych jest trudna. W wyniku wystąpienia działań niepożądanych leczenia, pacjenci mają wiele problemów. Wymagają profesjonalnej opieki i wsparcia. Stosowanie ICNP® w praktyce ułatwia pracę pielęgniarek.

Refine search results

The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

IgM multiple myeloma: diagnostic difficulties and results of bortezomib treatment – case report

Comparison of the free and total light chain assays in serum and urine samples with immunofixation electrophoresis for detecting monoclonal proteins in patients with monoclonal gammopathy

Advances in hematology – research that revolutionized patient care

Opieka pielęgniarska nad pacjentem ze szpiczakiem mnogim, po autologicznym przeszczepieniu krwiotwórczych komórek macierzystych – studium przypadku.