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Dependence of the yeast Saccharomyces cerevisiae post-reproductive lifespan on the reproductive potential

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Zadrag-Tecza R., Molon M., Mamczur J., Bilinski T.
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2013
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vol. 60
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issue 1
111-115
EN
The lifespan of budding yeast cells is divided into two stages: reproductive and post-reproductive. The post-reproductive stage of the yeast's lifespan has never been characterized before. We have analyzed the influence of various mutations on the post-reproductive (PRLS) and replicative (RLS) lifespans. The results indicate that PRLS demonstrates an inverse relationship with RLS. The observed lack of differences in the total lifespan (TLS) (expressed in units of time) of strains differing up to five times in RLS (expressed in the number of daughters formed) suggests the necessity of revision of opinions concerning the use of yeast as a model organism of gerontology.
2
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Human Body, Consciousness and Identity in the Mirror of Life Interviews with Female Coaches

100%
Bodnár I.
Physical Culture and Sport. Studies and Research
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2009
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vol. 46
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issue 1
208-219
EN
One of the recurring themes when conducting life-interviews with women coaches is their confrontation with the fact that their physique does not correspond to the body-frame considered to be ideal in their respective sports disciplines. Since they can preserve their athletic identity only with the help of their physique, the course of their careers depends on the solution they find to this problem. The study presents this decision-making process using Luhmann's systems theory: as an environmental interaction between a neurophysiological (the body), a psychological (the identity of women coaches) and a social (sports) system. It looks upon this situation as a communication between female athletes and competitive sport as a social system, in which observation is accorded an outstanding role. Assuming the role of an observer, female athletes see the series of movements and solutions that their coach does not recognize. Instead of physical perfection, they develop the individual perfection of movement execution.
3
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Targeting FOXOs to slow aging

100%
Martins R., Dumas K. J., Lithgow G. J.
Molecular inhibitors in targeted therapy
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2015
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vol. 1
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issue 1
EN
The key importance of FOXO transcription factors and related pathways in the process of aging renders them compelling targets in the quest for compounds that could slow down the aging process. In this review, we give a brief overview of what we know about the role of FOXO proteins in aging and longevity and describe how this knowledge might be of value in developing future therapies aimed at extending lifespan and health span in people. Given the potential of FOXO proteins to impact on a variety of disorders such as cancer, diabetes, neurodegeneration or immune system dysfunction, novel therapeutic approaches based FOXO-targeting strategies are expected to be a fertile area of research in the near future.
4
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The links between hypertrophy, reproductive potential and longevity in the Saccharomyces cerevisiae yeast

100%
Molon M., Zadrag-Tecza R.
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EN
The yeast Saccharomyces cerevisiae has long been used as a model organism for studying the basic mechanisms of aging. However, the main problem with the use of this unicellular fungus is the unit of "longevity". For all organisms, lifespan is expressed in units of time, while in the case of yeast it is defined by the number of daughter cells produced. Additionally, in yeast the phenotypic effects of mutations often show a clear dependence on the genetic background, suggesting the need for an analysis of strains representing different genetic backgrounds. Our results confirm the data presented in earlier papers that the reproductive potential is strongly associated with an increase in cell volume per generation. An excessive cell volume results in the loss of reproductive capacity. These data clearly support the hypertrophy hypothesis. The time of life of all analysed mutants, with the exception of sch9D, is the same as in the case of the wild-type strain. Interestingly, the 121% increase of the fob1D mutant's reproductive potential compared to the sfp1D mutant does not result in prolongation of the mutant's time of life (total lifespan).
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