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Lactoferrin-monophosphoryl lipid a complex enhances immunity of mice to Plesiomonas shigelloides CNCTC 138/92

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Chodaczek G., Zimecki M., Lukasiewicz J., Lugowski C.
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2008
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vol. 55
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issue 1
91-96
EN
Our previous study showed the efficacy of lactoferrin-monophosphoryl lipid A isolated from Hafnia alvei LPS complex (LF-MPLH.a.) as an adjuvant in stimulation of humoral and cellular immune response in mice to conventional antigens and a lower pyrogenicity of the complex as compared with MPLH.a. alone. In the present investigation we demonstrated that LF-MPLH.a. complex enhanced the immunity of BALB/c mice immunized with Plesiomonas shigelloides CNCTC 138/92 bacterial vaccine, against P. shigelloides infection. The adjuvant effect was evidenced by a significant increase of the antigen-specific serum IgG, IgG2a, and IgG1 and elevation of antigen-specific serum IgA concentrations. In addition, application of the adjuvant facilitated better clearance of the bacteria in spleens and livers of infected mice when compared with MPLH.a. alone. These features of the new adjuvant may predispose it for vaccination protocols in humans.
2
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The Biological Properties Of Lactoferrin

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Trybek G., Metlerski M., Szumilas K., Aniko-Włodarczyk M., Preuss O., Grocholewicz K., Wiszniewska B.
Central European Journal of Sport Sciences and Medicine
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2016
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vol. 15
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issue 3
15-25
EN
Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions from exocrine glands and the content of specific granules of neutrophils. It has been reported to have numerous functions. Due to antimicrobial and anti-inflammatory activity, the lactoferrin plays significant role in host defense against infection and extreme inflammation. Recent studies have also demonstrated that LF can protect against cancer in experimental animals and has anticarcinogenic activity in many human tumors. At the cellular level, LF modulates the proliferation, differentiation, maturation, activation, migration and function of immune cells. This review presents the multifunctional roles and specific beneficial properties of lactoferrin.
3
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Combined therapy: rifaximin-α and arabinogalactan with lactoferrin combination effectively prevents recurrences of symptomatic uncomplicated diverticular disease

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Pietrzak A. M., Banasiewicz T., Skoczylas K., Dziki A., Szczepkowski M.
Polish Journal of Surgery
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2020
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vol. 92(2)
22-28
EN
Background: Diverticulosis is the most common finding in the GI tract. Nearly half of the people with diverticula experience symptomatic uncomplicated diverticular disease (SUDD). Aims: The primary endpoints of our study were to assess the effectiveness of combined therapy with rifaximin-α and arabinogalactan-lactoferrin in symptom reduction and normalization of bowel movements. The secondary endpoints were an assessment of efficacy in SUDD recurrence prevention and patients’ compliance to the combined therapy. Material and methods: A retrospective observational survey study was performed in 2019 among physicians experienced in diverticular disease (DD) treatment in Poland. Patients with previous episodes of recurrences treated with combined therapy (cyclic rifaximin-α at least 400 mg b.i.d/7 days/every month and continuous arabinogalactan-lactoferrin supplementation 1 sachet daily) were assessed after 3 and 6 months regarding symptoms’ resolution in the three-point scale. The patients’ SUDD history, diagnostic methods, treatment, and results, as well as patients’ compliance were evaluated. Results: 281 patients met inclusion criteria, and were further evaluated (67.6% women, median age 65 years). After 6 months of combined treatment, there was statistically significant reduction in the total severity score (sum from 8.5 [max 15 points] to 1.28; p < 0.0001); and improvement in each symptom score (median from 1.7 [max 3 points] to 0.26; p < 0,001). Stool frequency statistically normalized in every group. As many as 31.7% had complete symptom resolution. Patients’ compliance with the therapy was very good and good in 92.9% of cases. Conclusions and discussion: Combined therapy with cyclic rifaximin-α and continuous arabinogalactan combination with lactoferrin is effective in SUDD treatment in terms of symptom resolution, bowel movement normalization, prevention of recurrences with very good patient’s compliance.
4

Zastosowanie laktoferryny w profilaktyce i leczeniu zaburzeń metabolicznych

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Rakuś-Kwiatosz A., Pac-Kożuchowska E.
Endokrynologia Pediatryczna
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2014
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vol. 13
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issue 2 (47)
77-83
EN
Nowadays, the metabolic syndrome is more frequently diagnosed among children and adolescents due to the growing epidemic of obesity. Therefore, studies are being conducted on the effects of substances of natural origin that could have a supporting effect as for the reduction of the adipose tissue. One of them is lactoferrin (LF) – an iron binding glycoprotein, produced by glandular epithelial cells and neutrophils. It is present in all secretions, but the highest concentration of LF can be found in mammals’ milk. LF receptors are localized on variety of cells such as monocytes, lymphocytes, adipocytes, hepatocytes and endothelial cells. So far its multidirectional actions such as: anti-inflammatory, antibacterial, antiviral, mmunomodulatory, antioxidant and anticancer have been widely known, but not much has been noted concerning the influence of the protein on lipid and carbohydrate homeostasis. The paper presents an overview of the research and clinical observations, with people’s participation, on the possible effects of LF in the view of beneficial influence on the disorders which are the elements of metabolic syndrome, with reference to selected actions of LF described in animal investigations or in vitro tests. Due to the complex and beneficial effects on lipid and carbohydrate homeostasis parameters, studies on its practical use are still in progress. Pediatr. Endocrinol. 13/2014;2(47):77-84.
PL
Zespół metaboliczny jest coraz częściej rozpoznawany w populacji dzieci i młodzieży, co wiąże się ze wzrastającą epidemią otyłości. Dlatego też trwają badania nad działaniem naturalnie występujących substancji, które mogłyby mieć wspomagający efekt w walce z nadmiarem tkanki tłuszczowej. Jedną z nich jest laktoferryna (LF) – glikoproteina wiążąca żelazo, produkowana przez komórki gruczołowe nabłonka oraz przez granulocyty obojętnochłonne. Obecna jest we wszystkich wydzielinach, a w największym stężeniu występuje w mleku ssaków. Jej receptory zlokalizowane są na różnorodnych komórkach, w tym monocytach, limfocytach, adipocytach, hepatocytach i komórkach śródbłonka. Dotychczas poznano jej wielokierunkowe działanie: przeciwzapalne, przeciwbakteryjne, przeciwwirusowe, immunomodulujące, przeciwutleniające i przeciwnowotworowe, natomiast mniej znany jest wpływ tego białka na gospodarkę lipidową i weglowodanową. Niniejsza praca prezentuje przegląd badań i obserwacji klinicznych z udziałem ludzi nad możliwymi efektami działania tego białka w perspektywie korzystnego wpływu na zaburzenia będące elementami zespołu metabolicznego, z odwołaniem do wybranych mechanizmów działania LF, opisanych dzięki doświadczeniom in vitro bądź na zwierzętach. Ze względu na złożony i korzystny wpływ omawianego białka na parametry gospodarki lipidowej i węglowodanowej stale trwają prace nad jego praktycznym zastosowaniem. Endokrynol. Ped. 13/2014;2(47):77-84.
5
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Potential immune modulating properties and antioxidant activity of supplementing commercially available lactoferrin and/orLactobacillus sp. in healthy Ossimi lambs

63%
El-Ashker M., Risha E., Abdelhamid F., Ateya A., El-Ashker M., Risha E., Abdelhamid F., Ateya A.
Polish Journal of Veterinary Sciences
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2018
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vol. 21
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issue 4
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