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Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.

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Gackowski D., Kruszewski M., Banaszkiewicz Z., Jawien A., Olinski R.

2002

vol. 49

issue 1

269-273

Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.

Iron-sulfur cluster proteins: electron transfer and beyond

100%

Brzóska K., Męczyńska S., Kruszewski M.

2006

vol. 53

issue 4

685-691

Iron-sulfur clusters-containing proteins participate in many cellular processes, including crucial biological events like DNA synthesis and processing of dioxygen. In most iron-sulfur proteins, the clusters function as electron-transfer groups in mediating one-electron redox processes and as such they are integral components of respiratory and photosynthetic electron transfer chains and numerous redox enzymes involved in carbon, oxygen, hydrogen, sulfur and nitrogen metabolism. Recently, novel regulatory and enzymatic functions of these proteins have emerged. Iron-sulfur cluster proteins participate in the control of gene expression, oxygen/nitrogen sensing, control of labile iron pool and DNA damage recognition and repair. Their role in cellular response to oxidative stress and as a source of free iron ions is also discussed.

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2 Acta Biochimica Polonica

1 2006

1 2002

2 Kruszewski M.

1 Banaszkiewicz Z.

1 Brzóska K.

1 Gackowski D.

1 Jawien A.

1 Męczyńska S.

1 Olinski R.

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Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.

Iron-sulfur cluster proteins: electron transfer and beyond