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Kinobeon A, purified from cultured safflower cells, is a novel and potent singlet oxygen quencher

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Kambayashi Y., Takekoshi S., Nakano M., Shibamori M., Hitomi Y., Ogino K.

2005

vol. 52

issue 4

903-908

We recently reported that kinobeon A, produced from safflower cells, suppressed the free radical-induced damage of cell and microsomal membranes. In the present study, we investigated whether kinobeon A quenches singlet oxygen, another important active oxygen species. Kinobeon A inhibited the singlet oxygen-induced oxidation of squalene. The second-order rate constant between singlet oxygen and kinobeon A was 1.15 × 1010 M-1s-1 in methanol containing 10% dimethyl sulfoxide at 37°C. Those of α-tocopherol and β-carotene, which are known potent singlet oxygen quenchers, were 4.45 × 108 M-1s-1 and 1.26 × 1010 M-1s-1, respectively. When kinobeon A was incubated with a thermolytic singlet oxygen generator, its concentration decreased. However, this change was extremely small compared to the amount of singlet oxygen formed and the inhibitory effect of kinobeon A on squalene oxidation by singlet oxygen. In conclusion, kinobeon A was a strong singlet oxygen quencher. It reacted chemically with singlet oxygen, but it was physical quenching that was mainly responsible for the elimination of singlet oxygen by kinobeon A. Kinobeon A is expected to have a preventive effect on singlet oxygen-related diseases of the skin or eyes.

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1 Acta Biochimica Polonica

1 2005

1 Hitomi Y.

1 Kambayashi Y.

1 Nakano M.

1 Ogino K.

1 Shibamori M.

1 Takekoshi S.

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Kinobeon A, purified from cultured safflower cells, is a novel and potent singlet oxygen quencher