Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 1

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  ionotropic gelation
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Publication available in full text mode
Content available

ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

100%
Gadziński P., Froelich A., Kowalska U., Soból M., Szybowicz M., Osmałek T.
Acta Poloniae Pharmaceutica - Drug Research
|
2020
|
vol. 77
|
issue 2
319-330
EN
The aim of the work was to investigate the properties of polysaccharide matrices loaded with roxithromycin (ROX), made on the basis of low-acyl gellan and its blends with sodium alginate, pectin, karaya gum, methycellulose and κ-carageenan. The obtained formulations were investigated as potential oral dosage forms with the ability to protect it from the acidic conditions of the stomach. Another desired feature of the obtained systems was the sustained release of the active ingredient allowing for potential shifting the therapeutic effect to the colon. The morphology of the matrices was evaluated with optical and scanning electron microscopy. Moreover, Raman spectroscopy and thermal analysis were performed for ROX, polymers, ROX/polymers physical mixtures and the matrices. Next, the swelling behavior was examined. The matrices were evaluated for ROX content and encapsulation efficiency. The last stage concerned the drug release studies. All matrices after production revealed more or less oval shape with visible deformation most probably occurring during drying. Raman analysis and DSC confirmed the crystalline form of ROX and showed no evidence of interactions between the drug and the excipients. It was shown that the matrices containing gellan combined with methylcellulose or κ-carageenan at pH=7.4 released ROX slower than the other matrices which might be promising in terms of colonic drug delivery. Moreover, the polymer matrices remained physically stable at acidic pH similar to the environment of the stomach. However, in these conditions drug degradation was observed which indicates the necessity to further modify the applied technology.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.