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1

The interaction of physical activity and the lif e quality of students in mid and late adolescence

100%

Broďáni J., Lipárová S., Kráľ M.

Physical Activity Review

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2016

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vol. 4

124-131

EN

The report presents the internship analysis results between the p hysical activity during the week and life quality fields in mid and late adolescence of students in different sport level. In the research took part students from secondary schools and universities from Slovakia (n=308). The life quality was observed via m odificated questionnaire SQUALA and the level of the physical activity during the week in hours (PA). The results are presented by descriptive characteristics (n, M, SD) and the statistic importance of differences, relations is rated by non – parametric me thods (W, U, r s ) at the levels of importance (p< 0. 05, p< 0. 20; p = level of significant = p - value = 1%, 5%, 10%, 20%).Positive interactions PA with life quality fields were found in mid adolescence. In the group of active athletes in mid adolescence were pr oved positive interactions with the f ield of physical well - being (p<0. 10), field of appearance and possession of things (p<,01), by occasional athletes with the spiritual field (p< 0. 01) and the field of education (p< 0. 20). In the group of students in late adolescence was proved a positive interaction PA only with the field of material safety (p<0.01).It was repeatedly proved that mid and late adolescence is a very stormy and unstable period of lifetime, mainly when talking about satisfaction with life qual ity. The importance of life quality plays a great role in the lives of adolescents. It was also pointed out that there are possibilities to influence the fields of life quality via physical activities, but especially the importance of creating sufficient c ircumstances to enhance the life quality in social environment of adolescents. The contribution was published via the grant resource MŠ SR KEGA 003UKF - 4/2016.

2

Impact of hydrochlorothiazide on the stability of two perindopril salts. Evaluation of the interaction with HPLC and ESI LC/MS methods

100%

Juszczak A., Stanisz B. J., Szczołko W., Pieszak M., Cielecka-Piontek J.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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vol. 75

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issue 5

1117-1125

EN

Perindopril (PER) belongs to the group of the angiotensin converting enzyme inhibitors and is widely prescribed antihypertensive drug. It can be used in monotherapy or in combination therapy for example with hydrochlorothiazide (HTH). As on the market there is no pharmaceutical formulation containing both drugs and in literature has not been reported any work about effect of HTH on PER degradation process, the primary objective of this study was the assessment of stability of two salts of perindopril - tert-butylamine (PERt) and arginine (PERa) in a mixtures model with HTH in different relative humidities and constant temperature. Objective of the study was establishing the mechanisms of drug decomposition in the presence of HTH. Results were achieved using the high performance liquid chromatography (RP-HPLC). The degradation rate constants for mixtures and pure substances were calculated. Decomposition products have been analyzed by ESI LC/MS and the decomposition mechanism for each salt has been proposed. The degradation of PERt in the presence of HTH took place according to autocatalytic reaction kinetic mechanism, described mathematically by Prout-Tompkins equation, and the decomposition process leads to hydrolysis. HTH in the model mixture with PERa generates a first-order kinetic model of the decomposition reaction, and there are two main products of decomposition: product of hydrolysis and diketopiperazine. Our study showed that HTH has statistically significant positive impact on both salts. It can be suggested that PERt or PERa and HTH can be formulated together, hence there is no negative interaction between the drugs.

3

Interaction of unmodified and partially silylated nanosilica with red blood cells

100%

Gun’ko V., Galagan N., Grytsenko I., Zarko V., Oranska O., Osaulenko V., Bogatyrev V., Turov V.

Open Chemistry

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2007

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vol. 5

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issue 4

951-969

EN

Interaction of red blood cells (RBCs) with unmodified and partially (50%) silylated fumed silica A-300 (nanosilica)was studied by microscopic, XRD and thermally stimulated depolarisation current (TSDC) methods. Nanosilica at a low concentration C A-300C A-300 = 1 wt% all RBCs transform into shadow corpuscles because of 100% haemolysis. Partial (one-half) hydrophobization of nanosilica leads to reduction of the haemolytic effect in comparison with unmodified silica at the same concentrations. A certain portion of the TSDC spectra of the buffered suspensions with RBC/A-300 is independent of the amounts of silica. However, significant portions of the low-and high-temperature TSDC bands have a lower intensity at C A-300 = 1 wt% than that for RBCs alone or RBC/A-300 at C A-300 = 0.01 wt.% because of structural changes in RBCs. Results of microscopic and XRD investigations and calculations using the TSDC-and NMR-cryoporometry suggest that the intracellular structures in RBCs (both organic and aqueous components) depend on nanosilica concentration in the suspension. [...]

4

Metals interaction tested in children’s hair originating from industrial and rural areas

100%

Kwapuliński J., Ciba J., Trzcionka A., Kluczka J., Brewczyński P. Z., Swoboda M., Fulczyk T., Szady B., Stykowska E., Trzcionka J.

Medycyna Środowiskowa - Environmental Medicine

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2014

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vol. 17

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issue 3

45-51

EN

Introduction. Different biological samples (blood, gallstone, teeth, hair) serve as a biomarker of exposure to metals for many years. This method appeared to be useful not only in clinical medicine, but also in the studies on the environment. Aim. The study is to compare the amount of selected metals in children’s hair residing in industrial and rural areas. Material and methods. Research of occurrence of 12 metals in children’s hair at the age of 7, 10 and 14 living in an industrial (Nowy Bytom town ) and a rural (Strumień town) areas has been presented. Determination of Pb, Cd, Ni, Co Na, K, Mg, Zn, Cu, Mn, Fe and Ca was carried out by atomic absorption spectrophotometry (AAS) using a spectrometer Perkin- Elmer 400. Results. In the case of seven-year old children, regardless of gender a common mechanism of co-occurrence was noticed for manganese and calcium, manganese and magnesium, calcium and magnesium, sodium and potassium. Apart from the correlation of metals for the seven-year-old-children mentioned, in case of ten-year old children, an additional correlation between calcium and zinc appears. Conclusion: The amount of some metals in the hair with the diversified possibility of interaction between the metals themselves and their relation to gender and age of children revealed different environmental exposure.

PL

Wstęp. Materiał biologiczny (krew, złogi pęcherzyka żółciowego, zęby, włosy) służy od lat jako biomarker ekspozycji na metale. Metoda ta okazała się być przydatna nie tylko w medycynie klinicznej ale również w badaniach nad środowiskiem. Cel pracy. Porównanie zawartości wybranych metali we włosach dzieci zamieszkałych na terenach przemysłowym i rolniczym. Materiał i metody. Zaprezentowano wyniki występowania 12 metali we włosach dzieci w wieku lat 7, 10 i 14, zamieszkujących tereny przemysłowy (Nowy Bytom) i rolniczy (Strumień). W celu dokonania oznaczeń Pb, Cd, Ni, Co, Na, K, Mg, Zn, Cu, Mn, Fe i Ca zastosowano absorpcyjną spektrometrię atomową. Wykorzystano spektrometr Perkin-Elmer 400. Wyniki. W przypadku dzieci 7- i 10-letnich dostrzeżono mechanizmy współwystępowania bez względu na płeć dla Mn i Ca, Mg i Mn, Ca i Mg, Na i K. Przy czym u dzieci 10 letnich dodatkowo wystąpiła współzależność pomiędzy Ca i Zn. Wnioski. Zawartość niektórych metali we włosach dzieci determinowana jest różną ekspozycją środowiskową, płcią i wiekiem badanych. Możliwa jest interakcja pomiędzy różnymi metalami.

5

Ecoenergetic cutting techniques

81%

Zaborowski T., Shvartsburg L., Ivanova N., Ryabov S., Zaborowski T., Shvartsburg L., Ivanova N., Ryabov S.

Management and Production Engineering Review

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2018

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vol. 9

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issue 4

Refine search results

The interaction of physical activity and the lif e quality of students in mid and late adolescence

Impact of hydrochlorothiazide on the stability of two perindopril salts. Evaluation of the interaction with HPLC and ESI LC/MS methods

Interaction of unmodified and partially silylated nanosilica with red blood cells

Metals interaction tested in children’s hair originating from industrial and rural areas

Ecoenergetic cutting techniques