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The -2518 A/GMCP-1Polymorphism as a Risk Factor of Inflammatory Bowel Disease

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Walczak A., Przybyłowska K., Sygut A., Dziki Ł., Chojnacki C., Chojnacki J., Dziki A., Majsterek I.
Polish Journal of Surgery
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2012
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vol. 84
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issue 5
238-241
EN
Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances.The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development.Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn's disease) as well as 210 healthy controls.Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn's disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively).Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
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