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Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats

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Najafian M., Ebrahim-Habibi A., Yaghmaei P., Parivar K., Larijani B.
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2010
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vol. 57
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issue 4
553-560
EN
trans-Chalcone is the core structure of naringenin chalcone, located halfway in the biosynthesis pathway of flavonoids. Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. As a mammalian alpha-amylase inhibitor in vitro, the putative beneficial effect of trans-chalcone on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1, and the results analyzed with commonly used statistical methods. Significant reduction of blood glucose levels and beneficial effect on dyslipidemia were observed in diabetic rats, as well as reduction of disturbing consequences of diabetes such as high urine volume and water intake. trans-chalcone was observed to have a weight loss-inductive effect, alongside with a reduction in food intake, which is suggestive of a therapeutic potential of this compound in overweight and obese patients.
2
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Hyperglycemia induced C2C12 myoblast cell cycle arrest and skeletal muscle atrophy by modulating sirtuins gene expression in rats

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Surinlert P., Thitiphatphuvanon T., Khimmaktong W., Pholpramool C., Tipbunjong C., Surinlert P., Thitiphatphuvanon T., Khimmaktong W., Pholpramool C., Tipbunjong C.
Polish Journal of Veterinary Sciences
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2021
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vol. 24
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issue 4
3
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Changes in the clinical characteristics of women with gestational diabetes mellitus — a retrospective decade-long single center analysis

100%
Wilk M., Cyganek K., Matejko B., Krzyżowska S., Lasoń I., Katra B., Zięba-Parkitny J., Witek P., Małecki M. T., Wilk M., Cyganek K., Matejko B., Krzyżowska S., Lasoń I., Katra B., Zięba-Parkitny J., Witek P., Małecki M. T.
Folia Medica Cracoviensia
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2020
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vol. 60
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issue 4
4
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Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells

84%
Garczorz W., Francuz T., Gmiński J., Likus W., Siemianowicz K., Jurczak T., Strzałka-Mrozik B.
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2011
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vol. 58
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issue 3
375-379
EN
Endothelial dysfunction plays an important role in the development of atherosclerosis. Elastin-derived peptides (EDP), hyperglycemia, hypercholesterolemia and oxidized LDL have a proven proatherosclerotic potential. Nitric oxide generated by endothelial nitric oxide synthase (eNOS; EC 1.14.13.39) is an important vasorelaxant. Here we studied the influence of those proatherosclerotic factors on eNOS gene and protein expression in artery-derived endothelial cells. Human umbilical artery endothelial cells (HUAEC) were incubated with or without: glucose (270 mg/dl), LDL (200 mg/dl), oxidized LDL (oxLDL 25 mg/dl) or κ-elastin (0.5 and 2.5 µg/ml). Gene expression was assessed by real time RT-PCR, whilst the eNOS protein by ELISA. In cells incubated with 2.5 µg/ml of κ-elastin, a 31 % increase of eNOS mRNA expression was observed, but the protein level remained unchanged. OxLDL, LDL and glucose decreased the eNOS protein level by 74 %, 37 % and 29 %, respectively. OxLDL decreased eNOS mRNA by 42 %. LDL non-significantly decreased eNOS mRNA expression. An elevated glucose level did not affect the eNOS mRNA expression. Hyperglycemia and an elevated level of LDL, particularly oxLDL, decreased the level of eNOS protein in endothelial cells. As κ-elastin did not decrease the expression of eNOS gene in HUAEC, the proatherogenic properties of elastin-derived peptides are unlikely to be due to their influence on eNOS.
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