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Synthesis, Antimicrobial and Antioxidant Activities of Some Naphthalene - Containing Hydrazone Derivatives

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Sivasankari S., Rubala mary M.
World News of Natural Sciences
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2018
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vol. 18
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issue 2
124-132
EN
The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic resistant pathogens. This necessitates an ever-increasing search for new drugs. In an effort to develop antimicrobial agents, a series of hydrazone 2-6-derivatives were synthesized. These were characterized on the basis of physical and spectroscopic data, and were evaluated for their antimicrobial activity against various bacterial and fungal strains using the disc diffusion method and nutrient agar media. The antioxidant activities of the products were also evaluated. Our data showed that many derivatives have promising activities as antioxidant agents.
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The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

86%
Łazarenkow A., Michalska M., Gorąca A., Mirowski M., Nawrot-Modranka J., Piechota-Polanczyk A.
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2013
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vol. 60
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issue 2
259-262
EN
Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
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