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Development of tablets containing solid dispersion of ibuprofen manufactured by Hot Melt Impregnation process.

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Garbera K., Woś-Latosi K., Sawicki W.
Acta Poloniae Pharmaceutica - Drug Research
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2019
|
vol. 76
|
issue 2
341-354
EN
The main assumption of given study was to develop tablets containing amorphous ibuprofen by hot melt extrusion process. However proposed manufacturing procedure demonstrates quite a few differences in comparison to a conventional hot melt extrusion. Accurately the given manufacturing procedure has been called a hot melt impregnation due to the process characteristics. As a product of described process a fine free flowing extrudate is obtained. Four different compositions have been proposed. Materials prepared by hot melt impregnation technique have been extensively examined in terms of physicochemical properties and then were subjected to tablet compression process. Obtained tablets were examined in terms of thermodynamic stability and compared to marketed product containing ibuprofen.
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