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Anti-breast cancer potential of honey: a narrative review

100%
Qadirifard M. S., Fathabadi A., Hajishah H., Gholami K., Abbasi M., Sami N., Zo M. M., Kadkhodaei F., Sina M., Ansari A., Rahimi Z., Deravi N.
OncoReview
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2022
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vol. 12
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issue 1
5-15
EN
Cancer is responsible for the death of millions of people all around the world. Among the large group of cancers, the prevalence of breast cancer is highest in women. Therapeutic interventions, including removal surgery, radiation therapy, hormone therapy, and chemotherapy which is largely used, may cause adverse effects on the quality of patients’ life. This fact has encouraged researchers to find natural substances such as honey to overcome harmful effects. Nowadays, honey is recommended for plenty of abnormalities because of its antioxidant, anti-inflammatory, and antimicrobial properties. Various studies have been conducted to explore the anticancer benefits of different types of honey from different origins. In this review, we are going to summarize in-vitro, animal, and human studies on the anti-breast cancer potential of honey.
2
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PREPARATION AND CHARACTERIZATION OF CHITOSAN-AGAR FILMS

88%
Joanna Wolska J. W., Setkowicz J., Maliszewska I. H.
Progress on Chemistry and Application of Chitin and its Derivatives
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2020
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vol. 25
210 - 226
EN
Hydrogel films composed of chitosan and agar or chitosan, agar and honey/bee pollen were prepared; they could be used as active wound dressings. During this study, various types of gel films were prepared using chitosan with different molecular weights and ratios of the two biopolymers. In addition, compositions with different amounts of honey or bee pollen were obtained. The selected samples were characterized by determining typical properties that are important for wound dressings. The best twocomponent films had a chitosan to agar weight ratio of 2:1. From among the examined tri-component films, the 2:1:0.5 weight ratio of chitosan, agar and 50 wt% honey solution was the best composition.
3
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Transverse study of the perception and uses of honey as a complementary and alternative medicine in Ibadan, Nigeria

88%
Ibitoye O. S.
World News of Natural Sciences
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2019
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vol. 25
1-14
EN
Honey is the focus of many research projects for its varied biological activities. It is an age-old remedy that is currently being rediscovered as a complementary and alternative medicine (CAM) to be used in modern medicine. The present study aims to investigate the use and perception of honey as CAM among the general public in Ibadan metropolis. A cross sectional study was conducted using three local government areas in Ibadan, a structured and tested questionnaire was then adopted with readjustment. A total of 405 questionnaires were randomly distributed within the study area. These indicate that 63.5% (257/405) of the respondents used honey as CAM, and age significantly affects the usage/ none usage of honey in the study area (p < 0.05). Many respondents claimed they use honey as a dietary supplement for general well-being (79%, 203/257), or for treating burns/wounds (76.3, 196/257), cough (72.8%, 187/257) and sore throat (60.3%, 155/257). A small percentage of the respondents used honey to treat ulcers (17.1%, 44/257). Our work also revealed that a limited number of the respondents (13%, 32/257) buy honey from pharmaceutical stores, while information regarding honey was majorly gotten from friends and family (70%, 180/257). In addition, respondents have favourable perception of the use of honey as CAM - as over 60% of them rated strongly agree and agree for each of the perception question. Respondents highlighted some risk factors affecting the use of honey as CAM, Among which inadequate information on the use of honey ranked highest (mean = 4.40), concerns were also raised on the quality (mean = 4.33) and high price of honey used (4.31). There are favourable perception of the use of honey as CAM, but issues relating to honey quality should be determined before use. Future work should be done to test the perception and acceptance level of honey as CAM among health workers.
4
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Investigation on the possibility to enhancing honey spray drying process and powders properties by ultrafiltration pre-treatment

88%
Samborska K., Barańska A., Bodel D., Jedlińska A.
Chemical and Process Engineering
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2019
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vol. 40
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issue 3
5
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TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF SELECTED HONEYS AGAINST HUMAN PATHOGENIC BACTERIA

88%
Živković J., Sunarić S., Stanković N., Mihajilov-Krstev T., Spasić A.
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EN
The study analyzed colour intensity, the total phenolic and flavonoid contents, as well as antioxidant and antibacterial activities of honeys from Serbia. All the tested honeys contained considerable levels of phenolics. The highest phenolic content was obtained in forest honey - 1389.71 mg gallic acid equivalents/kg. High levels of phenolics and flavonoids were also determined in honeydew, meadow and oregano honeys. The radical scavenging activity measured by DPPH method in linden and forest honey was 0.45 and 2.75 mmol Trolox equivalents/kg, respectively. The ferric reducing potential was the greatest in forest honey - 6.04 mmol Fe2+/kg. Darker honeys had a greater phenolic content and antioxidant activity. The antimicrobial activity of honeys against six bacterial strains isolated from human material were studied using a microwell dilution assay. The minimal inhibitory concentration of honeys ranged from 6.25% w/w (for oregano honey against Enterococcus faecalis and honeydew honey against Streptococcus pneumoniae) to >50% w/w (meadow honey against Staphylococcus aureus). The minimal bactericidal concentration ranged from 12.5% w/w (honeydew and bee pollen enriched honey against E. faecalis) to >50% w/w. Higher values of antimicrobial activities were found in honeydew, oregano, and forest honeys, while meadow honey showed the lowest antimicrobial activity. Analyzed honeys exhibited a strong antioxidant and broad-spectrum antibacterial activity against multidrug-resistant pathogenic bacteria. Phenolic compounds, especially in dark amber forest and honeydew honey, as well as in amber oregano honey, may contribute to their efficacy in therapeutic administration.
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