TT virus (TTV) was suggested to be the etiologic agent for non A-E hepatitis but this could not yet be proven due to high detection rates not only in hepatitis but also in healthy persons and sensitivity differences of PCR methods employed. The aim of this study was to evaluate TTV DNA positivity in non A-E hepatitis cases, chronic HBV and HCV hepatitis cases and healthy blood donors via PCR systems that target all regions of the viral genome used for viral detection. 23 non A-E hepatitis, 28 chronic HCV, 21 chronic HBV cases and 56 healthy blood donors were included in the study and evaluated by PCR protocols that target 5′-UTR, 3′-UTR and N22 (ORF1) regions. As a result, 3′-UTR and 5′-UTR PCR had comparable detection rates that were higher than N22 PCR. Differences in detection rates among study groups were not statistically significant for any PCR method. Hepatic enzyme levels of the patients were not correlated with the presence of TTV DNA. Detection rate was significantly higher for Non A-E hepatitis group when positivity rates from all methods were combined. These results suggest an alteration of viral genotypes in Non A-E hepatitis which might be associated with pathogenesis.
Introduction Most cases of hepatitis C affect patients between 20 and 40 years of age. This disease is a major diagnostic challenge due to the its insidious course. Aim The aim of this study is to analyse the quality of life of patients with hepatitis C, conditioned by the patient’s age. Material and methods The research was conducted among 101 people. The study used the estimation method and the diagnostic survey, the survey technique, while the tools used in the work are a standardized WHOQOL-Bref question¬naire. Results The age of the respondents did not remain in a statistically significant correlation with the results of quality of life and its subscales (p> 0.05). Conclusions The advanced age had impact on the lower level of quality of life of Hepatitis C patients
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Wstęp Najwięcej zachorowań na wirusowe zapalenie wątroby typu C dotyczy pacjentów między 20 a 40 rokiem życia. Choroba ta jest dużym wyzwaniem diagnostycznym ze względu na skąpoobjawowy przebieg. Cel Celem niniejszego opracowania jest analiza jakości życia pacjentów z WZW typu C uwarunkowana wie-kiem chorego. Materiał i metody Badania zostały przeprowadzone wśród 101 osób. Zastosowano w nich metodę szacowania oraz sondażu diagnostycznego, technikę ankietowania, natomiast narzędzia użyte w pracy to standaryzowany kwestiona¬riusz WHOQOL-Bref. Wyniki Wiek badanych nie pozostawał w istotnej statystycznie korelacji z wynikami jakości życia i jej podskal (p>0,05). Wnioski Zaawansowanie wieku pacjentów z WZW typu C wpływało na osiągnięcie niższego poziomu jakości życia.
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