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A retrospective analysis of thyroid dysfunction following multi-modality treatment of head & neck malignancies

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Malik J., Sharma A., Monga S., Alam S., Joshi A., Rasool S., Bahadur S.

Polski Przegląd Otorynolaryngologiczny

2020

vol. 9(3)

17-22

Introduction: The purpose of this study was to determine the incidence of radiation induced hypothyroidism after treatment with radiotherapy alone or in combination with surgery/chemotherapy in head & neck cancer patients. Methods: This study was a retrospective non-randomized trial performed on 100 patients of head & neck cancer in whom definitive radiotherapy, postoperative radiotherapy or radiotherapy in combination with chemotherapy was given. Values of TSH, T3 & T4 were analyzed at baseline and at 6 monthly follow-up. Subclinical hypothyroidism was defined as TSH value of > 4 mU/L and Clinical hypothyroidism was taken as TSH > 10 mU/L with decreased T3 & T4. Results: Out of 100 patients, 73 individuals were euthyroid at the end of 2-year follow-up, 21% had subclinical hypothyroidism and 6% had clinical hypothyroidism. The incidence of subclinical hypothyroidism in the surgery plus radiotherapy group and the radiotherapy group was 22.3% & 50%, respectively. The incidence of clinical hypothyroidism in the surgery plus radio therapy group and the radiotherapy group was 6.5% & nil, respectively. Conclusion: The incidence of hypothyroidism is high in head & neck cancer patients receiving radiotherapy. The risk is higher in patients who undergo surgery in combination with radiotherapy. Regular thyroid function test is, therefore, recommended.

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1 Polski Przegląd Otorynolaryngologiczny

1 2020

1 Alam S.

1 Bahadur S.

1 Joshi A.

1 Malik J.

1 Monga S.

1 Rasool S.

1 Sharma A.

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A retrospective analysis of thyroid dysfunction following multi-modality treatment of head & neck malignancies