Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 2

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  glucose metabolism
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Publication available in full text mode
Content available

The influence of selected bariatric surgeries on glycolipid balance

100%
Kruś-Hadała J., Cywiński J., Kaźmierski P., Kołomecki K.
Polish Journal of Surgery
|
2018
|
vol. 90(5)
17-21
EN
Aim: The aim of this study conducted in 2013–2015 was to compare the efficacy of two laparoscopic bariatric procedures, i.e., Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (LSG) in terms of body mass reduction and improvement in carbohydrate and lipid metabolism. Material and methods: The study group consisted of 20 patients subjected to RYGB (Group I) and 20 patients subjected to LSG (Group II) procedures. Body mass and fasting concentrations of glucose, insulin, glycated hemoglobin, total cholesterol, HDL, LDL and triglycerides were evaluated on the day preceding surgery and 1, 3 and 6 months thereafter. BMI, HOMA-IR and HOMA-B were calculated as well. Results: The reduction of BMI, glucose, insulin, glycated hemoglobin, triglycerides levels as well as HOMA-IR, and HOMA-B indexes and increase of HDL were observed in both groups 6 months after surgery. No reduction of both total cholesterol and LDL concentrations was obtained in both groups. The differences of studied parameters in both groups were not statistically significant. Conclusions: RYGB and LSG are equally effective in terms of body mass reduction, improvement of carbohydrates and lipid metabolism assessed 6 months after surgery.
2
Publication available in full text mode
Content available

Japanese quince (Chaenomeles japonica L.) fruit polyphenolic extract modulates carbohydrate metabolism in HepG2 cells via AMP-activated protein kinase

86%
Zakłos-Szyda M., Pawlik N.
|
2018
|
vol. 65
|
issue 1
67-78
EN
Type 2 diabetes mellitus (T2D) is a chronic diet-related disease which due to many dangerous complications has become a prominent health problem of the world. The aim of the study was to explore the in vitro activity of Japanese quince (Chaenomeles japonica L., family Rosaceae, JQ) fruit polyphenolic extract as modulator of carbohydrates metabolism. The research was designed to investigate the effect of JQ polyphenolic extract on glucose metabolism in human hepatoma HepG2 cell line cultured under normal non-metabolically changed and hyperglycemic conditions. Pretreatment of the cells with JQ preparation caused decrease of intracellular ROS generation and influenced mitochondrial membrane polarization which seemed to lead to AMPK activation. Further effects observed in HepG2 cells were associated with activation of the enzyme: elevation of glucose uptake and glycogen content, and alleviation of gluconeogenesis through modulation of PEPCK, PTP1B, FOXO1 and GLUT2/4 expression. These findings suggest that JQ polyphenols exhibit hypoglycemic effects via modulation of AMPK signaling in hepatocytes.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.