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Current strategies for the treatment of malignant gliomas – experience of the Department of Neurosurgery, Brodno Masovian Hospital in Warsaw

100%

Turek G., Pasterski T., Bankiewicz K., Dzierzęcki S., Ząbek M.

Polish Journal of Surgery

2020

vol. 92(5)

50-56

Introduction: Malignant gliomas (HGG) are the most common primary malignant brain tumors arising from glial cells. From among HGG, glioblastoma is the most common and the most malignant histological subtype, with only a 27% 2-year survival rate. Current standard medical treatment of malignant gliomas is still not satisfactory and may need some development and modification. We presented and discussed the achievements of the Department of Neurosurgery at Brodno Masovian Hospital in the treatment of malignant gliomas. Material and methods: We step by step presented and discussed the policy in the treatment of malignant gliomas. We showed all steps starting from the preparation of surgery (e.g. neuroimaging) and finishing on the presentation of the development of perioperative management – from intraoperative electrical stimulation mapping and monitoring which is nowadays already standard method to convection-enhanced delivery (CED) and gamma knife (GK) which are new and promising methods in the treatment of glioblastoma. Results: All surgical methods described in this manuscript were introduced to achieve a maximal and safe resection of a malignant glioma. CED and GK are the last-resort methods for patients with recurrent HGG. Discussion: Department of Neurosurgery at Brodno Masovian Hospital deals with all types of brain tumors, including all types of high-grade gliomas. As the first Department in Europe with close cooperation with the Department of Neurosurgery in San Francisco, we have started local infusions of drugs directly to the tumor in the real time of magnetic field, and we think that this technology may change all approaches to the treatment of high-grade gliomas.

Klinicznie nieczynne hormonalnie guzy przysadki

51%

Zawada N. B., Kunert-Radek J.

Folia Medica Lodziensia

2012

vol. 39

issue 1

85-136

The significant progress made in recent years, especially in the field of imaging techniques and immunohistochemistry, enables an earlier diagnosis and the treatment of clinically non-functioning pituitary adenomas (NFPAs). In spite of this, these tumours still remain an important medical issue for a large number of specialities. The aim of this article is to provide an overview of the etiopathogenesis, diagnosis and treatment of clinically non-functioning pituitary adenomas with special reference to the development of highly advanced methods in surgery as well as radiotherapy and, especially, in pharmacotherapy.

Istotny postęp, jaki dokonał się w ostatnich latach, zwłaszcza w zakresie rozwoju diagnostyki obrazowej i badań immunohistochemicznych, umożliwia wcześniejsze rozpoznawanie, a następnie leczenie nieczynnych hormonalnie gruczolaków przysadki (NFPAs). Mimo to guzy te dalej pozostają istotnym problemem klinicznym dla lekarzy wielu specjalności. Celem pracy jest szczegółowe przedstawienie poglądów na temat etiopatogenezy, obrazu klinicznego, diagnostyki i metod leczenia klinicznie nieczynnych hormonalnie gruczolaków przysadki ze szczególnym uwzględnieniem postępów w technikach chirurgicznych oraz rozszerzających się możliwości radioterapii, a szczególnie farmakoterapii.

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1 Folia Medica Lodziensia

1 Polish Journal of Surgery

1 2020

1 2012

1 Bankiewicz K.

1 Dzierzęcki S.

1 Kunert-Radek J.

1 Pasterski T.

1 Turek G.

1 Zawada N. B.

1 Ząbek M.

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Current strategies for the treatment of malignant gliomas – experience of the Department of Neurosurgery, Brodno Masovian Hospital in Warsaw

Klinicznie nieczynne hormonalnie guzy przysadki