Search results

Search:
in the keywords: gabapentin

Sort By:

Limit search:

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

100%

Wlaz A., Kondrat-Wrobel M. W., Zaluska K., Kochman E., Rekas A. R., Luszczki J. J.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 3

204-207

This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

Refine search results

1 Current Issues in Pharmacy and Medical Sciences

1 2015

1 Kochman E.

1 Kondrat-Wrobel M. W.

1 Luszczki J. J.

1 Rekas A. R.

1 Wlaz A.

1 Zaluska K.

Search results

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis