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QUANTITATIVE AND QUALITATIVE ANALYSIS OF FIXED-DOSE-COMBINATION PRODUCTS (FDC, POLYPILL) APPLIED IN POLYTHERAPY OF HYPERTENSIVE DISEASE. REVIEW

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Stolarczyk M., Apola A., Maślanka A., Kwiecień A., Opoka W.
Acta Poloniae Pharmaceutica - Drug Research
|
2018
|
vol. 75
|
issue 5
1083-1094
EN
Problems in polytherapy of hypertension combined with hyperlipidemia and the need of application of several pharmaceutical preparations have been widely explored by patients, physicians, and the pharmaceutical industry through testing and introduction of a fixed-dose-combination products (FDC). The paper presents different analytical methods of qualitative and quantitative analysis or stability testing of FDC preparations and laboratory prepared mixtures of composition consistent with the FDC products collected on the basis of publications from the last decade. It can significantly facilitate the study of the methods and conditions for the determination of active substances in polypills which contain at least three APIs, especially in cases involving this type of preparations used or tested for their application in polytherapy of hypertension.
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