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Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination

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Brillowska A., Dąbrowski S., Rułka J., Kubiś P., Buzała E., Kur J.
Acta Biochimica Polonica
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1999
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vol. 46
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issue 4
971-976
EN
The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).
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