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A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets.

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Mužíková J., Novotná A., Bartoš M.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 2

355-365

Avicel HFE-102 is a co-processed dry binder containing 90 % microcrystalline cellulose and 10 % mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel PH-102) and mannitol (Pearlitol 100SD) in the ratio of 9:1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friablity and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel PH-102 alone. The flow properties of the co-processed dry binder Avicel HFE-102 alone and the physical mixture were comparable. Avicel HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient Avicel® HFE-102 is suitable for the use in orally dispersible tablets.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2019

1 Bartoš M.

1 Mužíková J.

1 Novotná A.

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A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets.