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Role of biomarkers and electrocardiography assessment as individual predictors of anthracycline cardiotoxicity in lymphoma patients

100%

Długosz-Danecka M., Jaroszyński A., Jurczak W.

vol. 8

issue 4

99-104

The significant progress in the treatment of non-Hodgkin lymphomas, translating into prolongation of overall survival results in the manifestation of long-term adverse events, like anthracycline-related cardiotoxicity. Despite the dose-dependent cardiac dysfunction and the presence of risk factors, the increasing probability of cardiotoxicity arises from individual predisposition. Identification of high- -risk patients gives the opportunity to implement the prevention strategies to reduce the incidence of cardiac complications. The study evaluated the utility of biomarkers: N-terminal B-type natriuretic peptide, troponin I and electrocardiography with spatial QRS-T angle assessment, as indicators of individual sensitivity of cardiomyocytes to doxorubicin resulting in myocardial damage. Thirty-five treatment-naïve patients at increased risk of cardiotoxicity, were subjected prospectively during (R)-CHOP treatment to echocardiographic assessment and analysis of biomarkers: TnI and NT-proBNP plasma level and spatial QRS-T assessment before and 24 hours after each cycle of chemotherapy. The analysis of QRS-T angle was consistent with the results of NT-proBNP assessment and allowed to identify, after the first cycle of chemotherapy, patients at increased risk of developing cardiovascular complications, who require thorough echocardiographic analysis and primary cardioprotection implementation. Our data did not reveal the role of TnI in the identification of cardiac events. Our findings, though promising, should be confirmed in a larger group of patients in real-life or clinical trials.

High resolution ECG and MCG mapping: simulation study of single and dual accessory pathways and influence of lead displacement and limited lead selection on localisation results

100%

Jazbinsek V., Hren R., Trontelj Z.

2005

vol. 53

issue 3

Electrocardiographic history of pulmonary arterial hypertension – from diagnosis, through pregnancy, to lung transplantation

86%

Bula K., Grabka M., Mizia-Stec K.

Annales Academiae Medicae Silesiensis

2023

issue 77

128-136

The frequency and nature of electrocardiographic changes in patients with pulmonary hypertension varies significantly depending on the severity of the illness. In mild cases, electrocardiogram (ECG) may be normal. We present the consecutive ECGs of a patient with pulmonary arterial hypertension (PAH) in the 5-year course of the disease – from diagnosis to lung transplantation. The described case shows the variability of ECG changes in correlation with the clinical state of the patient. The observed ECG abnormalities in PAH are reversible and in the presented case ECG normalized after lung transplantation.

Częstość i charakter zmian w zapisach elektrokardiograficznych u pacjentów z nadciśnieniem płucnym zna-cząco różni się zależnie od ciężkości choroby. U pacjentów z łagodnym nadciśnieniem płucnym zapis elektro-kardiograficzny (EKG) może być prawidłowy. W niniejszej pracy prezentujemy kolejne zapisy EKG pacjentki z tętniczym nadciśnieniem płucnym (pulmonary arterial hypertension – PAH) w 5-letnim okresie choroby – od postawienia diagnozy aż do przeszczepienia płuc. Opisany przypadek pokazuje różnorodność zmian w zapi-sach EKG, których nasilenie korelowało ze stanem klinicznym pacjentki. Obserwowane nieprawidłowości w zapisach EKG w przypadku PAH są odwracalne i w prezentowanym przypadku doszło do ich normalizacji po przeszczepieniu płuc.

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1 Annales Academiae Medicae Silesiensis

1 Bulletin of the Polish Academy of Sciences: Technical Sciences

1 OncoReview

1 2023

1 2018

1 2005

1 Bula K.

1 Długosz-Danecka M.

1 Grabka M.

1 Hren R.

1 Jaroszyński A.

1 Jazbinsek V.

1 Jurczak W.

1 Mizia-Stec K.

1 Trontelj Z.

Search results

Role of biomarkers and electrocardiography assessment as individual predictors of anthracycline cardiotoxicity in lymphoma patients

High resolution ECG and MCG mapping: simulation study of single and dual accessory pathways and influence of lead displacement and limited lead selection on localisation results

Electrocardiographic history of pulmonary arterial hypertension – from diagnosis, through pregnancy, to lung transplantation