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EN
The impact of excipients contained in individual formulations on the pharmaceutical availability of folic acid was investigated. The release rate of the active substance and the disintegration time of the tablets were analysed. It has been found that in the presence of sorbitol, glucose and starch, 100% of folic acid is released within 60 minutes, and in the presence of lactose and starch - 95%, and the release rates for them are 0.0717 min-1 and 0.0555 min-1 respectively.
EN
Introduction. Increasing interest in dietary supplements designed for athletes is accompanied by an increase in the number of commercial vendors offering a broad range of dietary supplements. It is also followed by phenomenon of wide availability and as a consequence universality of application of this group of preparations. The goal of this research project was to assess the use of dietary supplements by players of selected sports with consideration given to sex, age, education, level of physical activity and training experience. Material and methods. The study was conducted using the diagnostic survey method with the aid of a survey written by the authors themselves. The study population consisted of 216 athletes (100 powerlifters and 116 volleyball players) ages 16÷30. Statistical analysis of empirical material was conducted on the χ2 basis of an test (p≤0.05 or higher). Results. A clear majority of subjects claimed to be convinced that diet and dietary supplementation exerted an important influence on their athletic performance. Despite giving their own diet a favorable assessment, more than 95% of respondents reported having difficulty following the diet, while simultaneously reporting the causes of this difficulty. The subjects rated their knowledge of how diet and supplementation enhance athletic performance as either average or very good. Their primary sources of knowledge on this subject were: the Internet, periodicals and promotional materials. The role of trainers, dieticians and physiologists was relatively insignificant. Around 64% of subjects reported general use of dietary supplements, while 72.7% claimed dietary supplementation to have a positive influence on their fitness and efficiency. The popularity of supplement use depended on the character of the athletic discipline. The most frequently used supplements were, in order of popularity: vitamin and mineral preparations, creatine, carbohydrate and protein supplements, BCAA and caffeine. The subjects were convinced that supplements for athletes, despite the various contraindications concerning their use and the presence of substances banned in certain sports, are not harmful to their health. Conclusion. Use of dietary supplements by athletes is universal and depends on the type of sport played.
EN
Nowadays, because of irregular lifestyle, high level of stress dietary supplements (DS) are becoming more popular as a source of needful nutrients among millions of people all over the world. The main purpose of present study was to estimate prevalence of dietary supplement consumption in sport, motivation in DS usage and sources of information. Anonymous self-administered questionnaire was spread among students of medical faculty in the end of their fourth year of study. There were 218 students of the fourth year of the Medical Faculty, of which 60.1% were females and 39.9% were males. Males more often used or had been using dietary supplements than females. The most popular dietary supplement was whey protein. The most common aim among men was to build up muscle mass. It is possible to state conclusions that prevalence of using dietary supplement among students is similar to values reported previously in the literature. Males were definitely more often undertaking physical activity in the gym and that could be the reason why they were definitely more often using specific dietary supplements.
EN
The aim of the investigation was to review experimental articles and patents referring to corn-based nutritional products for sportspeople published in the period 1970–2019. Publications were searched in the ISI Web of Science and Scopus databases, as well as the Google Scholar and Google Patents internet search engines. Factorial combinations of the keywords (“Zea mays” or “maize” or “corn”) and (“athlete” or “sport”) were applied. Most papers and patents were published in the period 2010–2019 by researchers affiliated to the USA and China – the two largest global producers of corn. Altogether, 65 patents and 16 articles were recorded. Inventors patented food supplements based on corn-derived saccharides and proteins. Empirical articles were devoted to the impact of corn-based food products on health of sportspeople, evaluation of the impact of length of consumption on the metabolism and performance of athletes, as well the frequency of use and acceptance of nutritional products based on corn by sportspeople. Despite growing interest in the application of corn constituents in nutritional products for sportspeople, further investigations are strongly desirable.
EN
Bacopa monnieri (Scrophulariaceae) is a well-known plant and has been used by humans for several thousand years. In traditional Hindu medicine, it is one of the most important medicinal plants. The aim of the work was to determine the content of Fe, Mg, and Zn and selected organic compounds before and after extraction into the artificial digestive juices obtained from preparations containing B. monnieri. Commercial preparations in the form of tablets and capsules and B. monnieri shoot cultures were used in the experiment. The metal content in the considered mineralized samples was analyzed by atomic absorption spectrometry and organic compounds by RP-HPLC method. The maximum measured content of the metals released into the digestive juices was as follows: Fe – 32.85; Mg – 367.51; and Zn – 16.41 mg/100 g of the preparation. The existing research shows that metals are best released into the artificial digestive juices from the B. monnieri shoot cultures, and least efficiently from the commercial preparations available in the form of tablets. The phenolic compounds analyzed in the methanol extracts and the extracts of the artificial digestive juices were as follows: protocatechuic acid, p-hydroxybenzoic acid, neochlorogenic acid, chlorogenic acid, isochlorogenic acid, caffeic acid, ferulic acid, cynaroside, trifolin, and luteolin. Bacoside A was only determined in the extracts from the B. monnieri shoot cultures. The experimental results revealed that B. monnieri distributed in the form of tablets did not break down in the artificial digestive juices during the considered time intervals.
EN
Herbal and nutritional supplements are more and more popular in the western population. One of them is an extract of an exotic plant, named Tribulus terrestris (TT). TT is a component of several supplements that are available over-the-counter and widely recommended, generally as enhancers of human vitality. TT is touted as a testosterone booster and remedy for impaired erectile function; therefore, it is targeted at physically active men, including male athletes. Based on the scientific literature describing the results of clinical trials, this review attempted to verify information on marketing TT with particular reference to the needs of athletes. It was found that there are few reliable data on the usefulness of TT in competitive sport. In humans, a TT extract used alone without additional components does not improve androgenic status or physical performance among athletes. The results of a few studies have showed that the combination of TT with other pharmacological components increases testosterone levels, but it was not discovered which components of the mixture contributed to that effect. TT contains several organic compounds including alkaloids and steroidal glycosides, of which pharmacological action in humans is not completely explained. One anti-doping study reported an incident with a TT supplement contaminated by a banned steroid. Toxicological studies regarding TT have been carried out on animals only, however, one accidental poisoning of a man was described. The Australian Institute of Sport does not recommend athletes’ usage of TT. So far, the published data concerning TT do not provide strong evidence for either usefulness or safe usage in sport.
Farmacja Polska
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2020
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vol. 76
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issue 4
195-202
EN
Glutathione (GSH) is a endogenous , low molecular weight thiol compound. It has a wide spectrum of biological activity in the body. It is an important element of the antioxidant system that protects cells against the effects of oxidative stress. As an antioxidant, GSH inactivates free radicals and reactive forms of oxygen and nitrogen in enzymatic and non-enzymatic reactions, regenerates other antioxidants, e.g. vitamins C and E, maintains - SH groups in proteins in a reduced state, participates in the detoxification of xenobiotics. The decrease in GSH concentration occurs in many diseases and in the aging process. Increasing the level of GSH in the body's cells is possible by consuming dietary components containing GSH or amino acids (especially cysteine) for its endogenous synthesis and supplementation with GSH pharmaceutical preparations. The aim of the study was to characterize dietary supplements available in Poland containing glutathione (GSH). The analysis covered 39 supplements from GSH, which were available in Poland. Their characteristics include: place / country of production; type of preparations (single and multi-component); bioavailability of GSH contained therein - preparations in the liposome formula (lipophilic GSH) and in the non-liposome formula (non-lipophilic GSH); pharmaceutical form in which these preparations were available on the commercial offer and GSH content in supplements. Among 39 GSH supplements, there were 24 single-component and 15 multi-component preparations. The largest number of GSH supplements available in Poland came from the USA and Great Britain. Among GSH supplements, there were 15 liposome (lipophilic) formula preparations, of which 12 were lipophilic one-component and 3 multi-component and 24 non-liposome (non-lipophilic) formula preparations - 12 single and 12 multi-component. Capsules, gel, liquid and tablets were the most common pharmaceutical form among all analyzed GSH supplements. The rarest pharmaceutical form was lozenges, aerosol, powder and ampoule. Analysis of GSH supplements available in Poland showed that in one single dose of the preparation was from 18 mg to 750 mg GSH. The most common dose was 250, 450 and 500 mg GSH in a single dose. One-component supplements most often contained 450 mg, then 250 and 500 mg GSH, while multi-component supplements - 250 mg GSH.
PL
Glutation (GSH) jest niskocząsteczkowym związkiem tiolowym, który wykazuje szerokie spektrum biologicznej aktywności. Jest ważnym elementem systemu antyoksydacyjnego chroniącego komórki przed skutkami stresu oksydacyjnego. Jako antyoksydant GSH unieczynnia wolne rodniki i reaktywne formy tlenu i azotu, regeneruje inne antyoksydanty np. witaminę C i E, utrzymuje grupy –SH w białkach w stanie zredukowanym, bierze udział w detoksykacji ksenobiotyków. Obniżenie stężenia GSH występuje w wielu schorzeniach. Zwiększenie poziomu GSH w komórkach organizmu jest możliwe poprzez spożywanie składników diety zawierających GSH, czy aminokwasy (szczególnie cysteina) do jego endogennej syntezy oraz suplementację preparatami farmaceutycznymi z GSH. Celem pracy była charakterystyka dostępnych w Polsce suplementów diety zawierających w swoim składzie glutation (GSH). Analizą objęto 39 suplementów z GSH. Ich charakterystyka uwzględnia: miejsce/kraj ich produkcji; typ preparatów (jedno- i wieloskładnikowe); biodostępność zawartego w nich GSH - preparaty w formule liposomowej (lipofilny GSH) i w formule nieliposomowej (nielipofilny GSH); postać farmaceutyczną preparatów oraz zawartość GSH w suplementach. Wśród 39 suplementów z GSH było 24 preparaty jedno- i 15 wieloskładnikowych. Największa liczba suplementów z GSH pochodziła z USA i Wielkiej Brytanii. Wśród suplementów z GSH było: 15 preparatów formuły liposomowej (lipofilnej ), z czego lipofilnych jednoskładnikowych było 12, a wieloskładnikowych 3 oraz 24 preparaty formuły nieliposomowej (nielipofilnej) - 12 jedno- i 12 wieloskładnikowych. Najczęściej występującą postacią farmaceutyczną wśród wszystkich analizowanych suplementów z GSH były kapsułki, żel, płyn i tabletki. W pojedynczej dawce preparatu znajdowało się od 18 mg do 750 mg GSH. Najczęściej znajdowało się 250, 450 i 500 mg GSH . Suplementy jednoskładnikowe najczęściej zawierały 450 mg GSH, natomiast wieloskładnikowe 250 mg GSH.
EN
Background. Dietary supplements (DS) are available over the counter, but patients with impaired renal function are specifically at risk for toxicity when consuming certain DS. The aim of this study was to evaluate the prevalence and characteristics of DS use in patients with chronic kidney disease (CKD). Material and methods. A cross-sectional, controlled DS use survey (22 questions) was conducted among 180 CKD patients (stage 1-5, dialysis, kidney transplant), with 60 patients without CKD serving as controls. Results. DS use did not differ significantly between subjects with and without CKD, unless the CKD patients were on dialysis. In the CKD group, 20% admitted to use DS regularly and 22% did not take the mat all. In the controls, DS consumption was 17% and 13%, respectively (NS). The DS use was higher among women ascompared to men (89% vs. 70%; p < 0.005), and people living in cities versus those living in the country side (81% vs. 63%; p < 0.05). DS most commonly used were: vitamins, minerals, and herbs. Major indications for DS use included: musculoskeletal issues, general health improvement and prevention of urinary tract infections. Subgroup analyses revealed that dialysis patients were characterized by a significantly higher DS use in comparison to CKD stage 1-5 subjects and renal transplant recipients. The decision to introduce DS was made by the physician in 54% of cases; by a pharmacist in 9% of cases, and by the patients themselves in 37%. Only 21% of patients with CKD, and 27% of subjects without CKD, declared knowledge of any possible side-effects associated with DS (NS). Conclusions. The use of DS among patients with CKD is similar to patients without CKD, with the exception of those on dialysis. Vitamins and minerals were the most commonly reported DS consumed. The knowledge on potential side-effectof DS was limited to approximately one-fourth of those surveyed.
EN
Objective of the study was to test dietary supplements available on the European market with regard to their iron content. Twenty-nine vitamin and mineral supplements were investigated, with additional assessment of their mass homogeneity. Iron was determined by means of the AAS1 method following microwave mineralization of particular samples. Findings were compared to iron contents declared by producers. Tested supplements were analysed with regard to the ratio between the amount of iron supplied to the body and the RDA2 for adults and pregnant women, as well as in view of the number of preparation pieces required to be taken in in order to ensure the RDA in the groups included in the research. All preparations were characterised by high mass homogeneity. The iron content determined in the supplements was different from the values indicated by the producers on the packages. Four supplements did not meet the European requirements concerning acceptable limits of nutrient tolerance stated on the labels. Tolerance for iron value in food supplements indicated by producers on packages varied from RDAs for the studied groups. The dosage recommended by the producer was mostly different from the dosage necessary to meet the requirements for iron RDA in the studied groups.
EN
SUBJECT OF RESEARCH: Nutricosmetics contain vitamin, mineral and biologically active compounds that have a positive effect on the appearance of the skin, nails and hair. The constantly growing consumption of dietary supplements, including preparations improving the condition of the skin of the hair and nails, promotes the creation of new preparations, but does not increase public awareness of the products used. RESEARCH OBJECTIVE: The aim of the study was to verify patients' knowledge of dietary supplements, with particular emphasis on preparations improving the condition of skin, hair and nails, as well as determining the factors determining the choice of a particular preparation. MATERIALS AND METHODS: The survey was conducted from December 2019 to April 2020 with the participation of a random group of 170 respondents, using the author's anonymous questionnaire containing 33 questions. RESULTS: Based on the results obtained, it can be said that 95% of respondents know the definition of a dietary supplement, but only 46.5% of respondents know that they are intended for healthy people, 54% of respondents declare taking dietary supplements that support the condition of the skin, hair and nails, 1/3 of respondents when choosing a preparation do not pay attention to whether it is a medicine or a dietary supplement, and 40% of respondents are not aware of the differences resulting from the different registration of both preparations. Over 70% of respondents buy dietary supplements at the pharmacy, but only a quarter of respondents use the pharmacist's professional advice. Almost 40% of respondents simultaneously use two or more dietary supplements, without being aware of the possibility of overdose of active substances contained in the preparations taken. Only half of the respondents are satisfied with the effects achieved thanks to the use of dietary supplements that improve the condition of the skin, hair and nails. CONCLUSIONS: Respondents have basic knowledge about dietary supplements used, but constant public education is needed regarding specialist knowledge regarding the quality and method of taking dietary supplements.
PL
PRZEDMIOT BADAŃ: Nutrikosmetyki zawierają związki witaminowe, mineralne i biologicznie aktywne, które wpływają korzystnie na wygląd skóry, paznokci i włosów. Stale rosnąca konsumpcja suplementów diety, w tym preparatów poprawiających kondycję skóry włosów i paznokci sprzyja powstawaniu nowych preparatów, jednak nie zwiększa to świadomości społeczeństwa w zakresie stosowanych produktów. CEL BADAŃ: Celem badania była weryfikacja wiedzy pacjentów na temat zażywanych suplementów diety, ze szczególnym uwzględnieniem preparatów poprawiających kondycję skóry, włosów i paznokci, a także określenie czynników, determinujących wybór określonego preparatu. MATERIAŁY I METODY: Badanie prowadzono od grudnia 2019 do kwietnia 2020 roku z udziałem losowej grupy 170 respondentów, za pomocą autorskiego, anonimowego kwestionariusza zawierającego 33 pytania. WYNIKI: Na podstawie uzyskanych wyników można stwierdzić, iż 95% respondentów zna definicję suplementu diety, jednak tylko 46,5% ankietowanych wie, że są one przeznaczone dla osób zdrowych, 1/3 respondentów podczas wyboru preparatu nie zwraca uwagi czy jest on lekiem czy suplementem diety, a 40% badanych nie ma świadomości różnic wynikających z odmiennej rejestracji obu preparatów. Ponad 70% badanych kupuje suplementy diety w aptece, jednak z fachowej porady farmaceuty korzysta jedynie ¼ respondentów. Niemal 40% ankietowanych stosuje jednocześnie dwa lub więcej suplementów diety, nie będąc świadomymi możliwości przedawkowania substancji czynnych zawartych w przyjmowanych preparatach. Jedynie połowa badanych jest zadowolona z efektów osiągniętych dzięki stosowaniu suplementów diety poprawiających kondycję skóry, włosów i paznokci. WNIOSKI: Respondenci posiadają podstawową wiedzę na temat stosowanych suplementów diety, jednak konieczna jest stała edukacja społeczeństwa w zakresie specjalistycznej wiedzy dotyczącej jakości i sposobu przyjmowania suplementów diety.
EN
Background. A properly composed diet is one of the key elements favorably affecting exercise capacity in athletes. Athletes increasingly often complement their diet by including dietary supplements in it. Due to the risk entailed by improper supplementation, it is justifiable to monitor supplement consumption. The aim of the study was to assess the consumption of dietary supplements by female football players at a competitive level of athletic performance. Material and methods. The study was conducted in a sample of 44 female football players, training at three league levels: ExtraLeague, I-League and II-League. The questionnaire included the questions about the period of training, diets, self-assessment of the participants’ knowledge on nutrition and supplementation. Additionally, measurements of body height and body mass were taken. Results. The sample included women aged 20.5±5 years; the subjects body height and body mass were 167.2±5 cm and 61.6±10.1 kg respectively and they trained on average 5 years or longer. 20.5% of the survey respondents reported taking dietary supplements, most of them (67%) within the period shorter than six months. The most frequent reported reasons for supplementation were: the desire to improve exercise capacity and/or someone’s recommendation. Most of the respondents (65%) reported a favorable effect of dietary supplementation. The football players learned about supplementation from their dieticians and/or the mass media. Conclusions: The female football players usually used supplements consciously and took only those with the effect confirmed by study results. Dietary supplements were usually taken with caution and the sources of knowledge of the supplements were in most cases reliable.
PL
Wstęp. Właściwie dobrana dieta jest jednym z kluczowych elementów wspomagania zdolności wysiłkowych sportowców. Sportowcy coraz częściej uzupełniają swoją dietę spożywając suplementy diety. Z uwagi na zagrożenia płynące z niewłaściwej suplementacji, zasadne jest jej monitorowanie. Celem pracy była ocena stosowania suplementów diety przez kobiety trenujące zawodowo piłkę nożną. Materiał i metody. Badanie przeprowadzono z udziałem 44 kobiet trenujących zawodowo piłkę nożną na 3 poziomach ligowych: ekstraligi, I ligi i II ligi. W ankiecie zadano pytania o staż treningowy, stosowanie diet, samoocenę wiedzy żywieniowej oraz suplementację. Dodatkowo dokonano pomiaru wzrostu i masy ciała. Wyniki. Badaną grupę stanowiły kobiety w wieku 20,5±5 lat, o wzroście 167,2±5 cm i masie ciała 61,6±10,1 kg, o stażu treningowym 5 lat lub więcej. 20,5% respondentek spożywało suplementy diety, w większości (67%) przez okres krótszy niż pół roku. Powodem suplementacji była przeważnie chęć polepszenie zdolności wysiłkowych i/lub zalecenia osób trzecich. Większość respondentek deklarowała pozytywne działanie suplementów diety (65%). Piłkarki czerpały przeważnie wiedzę na temat suplementów od dietetyka, trenera i/lub środków masowego przekazu. Wnioski. Piłkarki zazwyczaj prowadziły suplementację profesjonalnie, spożywały suplementy o potwierdzonym badaniami działaniu. Suplementy diety były zazwyczaj spożywane w sposób odpowiedzialny, a źródła wiedzy na ich temat – przeważnie rzetelne.
EN
INTRODUCTION: Musculoskeletal conditions are often characterized by pain, as well as limited physical function. To alleviate pain accompanying musculoskeletal diseases, non-steroidal anti-inflammatory drugs (NSAIDs) and/or paracetamol are used. Dietary supplements, however, are increasingly being considered by patients with these types of conditions as additional treatment aids. The aim of the study was the quantitative and qualitative analysis of dietary supplements and the subjective assessment of patients regarding the effect of supplements on the reduction of musculoskeletal disorders. MATERIAL AND METHODS: The study used the author’s own questionnaire to conduct a survey in a group of 171 patients, including 110 (64%) women and 61 (36%) men, of a rehabilitation clinic in Katowice. The survey questionnaire consisted of questions concerning, among others, the types of past injuries, the use of dietary supplements, as well as subjective feelings related to their use. RESULTS: Most respondents used preparations containing collagen (30.9%) and glucosamine (30%). Most of the respondents (43.6%) chose the supplement after consulting a doctor or physiotherapist. The large majority of respondents (65.4%) observed improvement after using the dietary supplement. CONCLUSIONS: The study showed that the majority of patients using dietary supplements that affect musculoskeletal function experienced improvements, most often after a month of taking them. Among the most commonly chosen dietary supplements were those that contained collagen and glucosamine in their formulation.
PL
WSTĘP: Schorzenia narządu ruchu często charakteryzują się bólem, a także ograniczoną sprawnością fizyczną. Dla zła-godzenia dolegliwości bólowych, towarzyszących chorobom układu ruchu, stosuje się niesteroidowe leki przeciwzapalne (non-steroidal anti-inflammatory drugs – NSAIDs) i/lub paracetamol. Suplementy diety są jednak coraz częściej brane pod uwagę przez pacjentów z tego typu schorzeniami jako dodatkowe środki wspomagające leczenie. Celem pracy była analiza ilościowa i jakościowa suplementów diety oraz subiektywna ocena pacjentów dotycząca wpływu przyjmowanych suplementów na zmniejszenie dolegliwości układu ruchu. MATERIAŁ I METODY: Narzędzie badawcze stanowił autorski kwestionariusz ankiety, przeprowadzony w grupie 171 pacjentów, w tym 110 (64%) kobiet oraz 61 (36%) mężczyzn, poradni rehabilitacyjnej w Katowicach. Kwestionariusz ankiety zawierał pytania dotyczące m.in. rodzajów doznanych urazów, stosowania oraz rodzaju przyjmowanych suplementów diety, a także subiektywnych odczuć związanych z ich stosowaniem. WYNIKI: Najwięcej respondentów stosowało preparaty zawierające kolagen (30,9%) oraz glukozaminę (30%). Większość ankietowanych (43,6%) dokonała wyboru suplementu po konsultacji z lekarzem lub rehabilitantem. Zdecydowana większość ankietowanych (65,4%) zauważyła poprawę po stosowaniu suplementu diety. WNIOSKI: Przeprowadzone badania wykazały, iż większość pacjentów stosujących suplementy diety wpływające na funkcjonowanie układu ruchu odczuwała poprawę, najczęściej po miesiącu ich przyjmowania. Do najczęściej wybieranych suplementów diety należały te, które w składzie zawierały kolagen oraz glukozaminę.
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