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  1. 1 Acta Biochimica Polonica

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  1. 1 2004

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  1. 1 Jazowiecka-Rakus J.

  2. 1 Szala S.

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Antitumour activity of Salmonella typhimurium VNP20047 in B16(F10) murine melanoma model.

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Jazowiecka-Rakus J., Szala S.
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vol. 51
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issue 3
851-856
EN
A tumour therapy is proposed based on attenuated Salmonella typhimurium VNP20047 expressing the Escherichia coli cytosine deaminase gene. VNP20047 was administered intravenously to B16(F10) melanoma-bearing C57BL/6 mice. VNP20047 proliferated within tumours and livers regardless of the initial inoculum dose. After 10 days the number of bacteria increased in livers up to 4.2 × 106 cfu/g and decreased in tumours down to 5.9 × 106 cfu/g. VNP20047 at 1 × 105 cfu/mouse, when combined with 5-fluorocytosine, inhibited tumour growth by 85% without prolonging animal survival. Histology studies revealed severe lesions in tumours and livers. These data suggest that S. typhimurium VNP20047 induced inflammatory responses, even though the strain was attenuated.
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