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The Effect of Acute Creatine Supplementation on Fatigue and Anaerobic Performance

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Ateş O., Keskin B., Bayraktar B.
Central European Journal of Sport Sciences and Medicine
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2017
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vol. 19
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issue 3
85-92
EN
The aim of this study is to investigate the effect of acute creatine monohydrate supplementation on fatigue and anaerobic performance. Thirty young soccer players participated in this study. Participants continued their training without taking any food supplements for 5 days, taking 0.3 g of milk dust per kg for 5 days and using 0.3 g creatine monohydrate per kg for 5 days. A total of 6 × 35 m sprint times were used in the fatigue index with a 10-second rest period between them. Single repeated sprint times of 35 m were examined as well. Statistically significant differences (p < 0.05) were found both fatigue index and single repeated 35 m sprint time after creatine supplementation. However there was not a statistically significant difference (p > 0.05) in Rast Test results. In soccer, it is known that there is a strong positive correlation between game performance and the number of repeated sprint numbers in a game. In conclusion, there was a statistically significant effect of 0.3 g of acute creatine loading per kg over 5 days on the single repeated sprints and fatigue index values. The creatine monohydrate can be used as an ergogenic aid for recovery periods between high-intensity exercises to affect performance.
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Effects of creatine hydrochloride supplementation on physical performance and hormonal changes in soldiers

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Tayebi M. M., Yousefpour M., Ghahari L.
Physical Activity Review
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2021
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vol. 1
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issue 9
93-99
EN
Purpose: The aim of this study was to examine the effects of 2 weeks of creatine hydrochloride (CrHCl) supplementation on physical performance and hormonal changes in army soldiers. Materials: Eighteen male army soldiers were randomly assigned in a double-blind fashion to either a CrHCl (n=9) or placebo (Pl) (n=9) groups. CrHCl group costumed 3g of creatine per day, whereas Pl group was given dextrose. Before and after supplementation period, the subjects performed a battery of performance tests including one repletion maximum (1RM) of bench press and back squat, vertical jump (VJ) and Wingate anaerobic test. In addition, blood samples were obtained to determine changes in testosterone and cortisol concentrations per and post supplementation. Results: There were significant increases in VJ, peak and mean power, and 1RM back squat test following the 2 weeks of CrHCl supplementation (p < 0.05) without any significant change for the Pl group. In addition significant changes were observed in testosterone and cortisol concentrations from before to after supplementation in CrHCl group (p < 0.05) and compared with Pl group (p=0.001). Conclusions: In conclusion, the present study indicates that CrHCl supplementation can improve VJ, power performance, 1RM back squat and hormonal changes in army soldiers.
3
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Is Long Term Creatine and Glutamine Supplementation Effective in Enhancing Physical Performance of Military Police Officers?

75%
Lázaro da Silveira C., Paiva de Souza T. S., Batista G. R., Targino de Araújo A., Gomes da Silva J. C., Cirilo de Sousa M. d. S., Marta C., Garrido N. D.
Journal of Human Kinetics
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2014
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vol. 43
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issue 1
131-138
EN
The objective of this study was to analyze the effect of supplementation with creatine and glutamine on physical fitness of military police officers. Therefore, an experimental double blind study was developed, with the final sample composed by 32 men randomly distributed into three groups: a group supplemented with creatine (n=10), glutamine (n=10) and a placebo group (n=12) and evaluated in three distinct moments, in an interval of three months (T1, T2 and T3). The physical training had a weekly frequency of 5 sessions x 90 min, including strength exercises, local muscular resistance, flexibility and both aerobic and anaerobic capacity. After analyzing the effect of time, group and interaction (group x time) for measures that indicated the physical capabilities of the subjects, a significant effect of time for the entire variable was identified (p<0,05). However, these differences were not observed when the univaried intragroups and intergroups analysis was performed (p>0,05). In face of the results it was concluded that supplementation with creatine and glutamine showed no ergogenic effect on physical performance in military police officers.
4
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SCL6A8 mutation in female patient resulting in creatine transporter deficiency

51%
Lewandowska Z., Steinborn B., Borkowski W., Chlebowska E., Karmelita-Katulska K.
Neurologia Dziecięca
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2018
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vol. 27
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issue 55
69-76
PL
Zespół mózgowego deficytu kreatyny jest zbiorczym terminem dla określenia różnych podtypów choroby, charakteryzującej się nieprawidłowym poziomem kreatyny w ośrodkowym układzie nerwowym. Jeden z nich, deficyt transportera kreatyny związany z mutacją w genie SCL6A8, jest częstą przyczyną niepełnosprawności intelektualnej związanej z chromosomem X. Typowo mutacja ta ulega pełnej ekspresji u pacjentów płci męskiej, jednakże kobiety również mogą prezentować niektóre z objawów, takie jak niepełnosprawność intelektualna w stopniu lekkim, problemy z uczeniem się i zaburzenia zachowania. Pacjent przedstawiony w poniższym opisie przypadku to 4-letnia dziewczynka ze zdiagnozowanym deficytem transportera kreatyny. U dziewczynki przeprowadzono diagnostykę genetyczną, w której zaobserwowano nieopisaną dotychczas w literaturze mutację w genie SCL6A8, oraz wykonano spektroskopię rezonansu magnetycznego, która wykazała typowy, nieprawidłowy poziom kreatyny w centralnym ukladzie nerwowym. Pacjentka prezentowała opóźnienie rozwoju mowy oraz rozwoju ruchowego, łagodną niepełnosprawność intelektualną, zaburzenia zachowania oraz napady padaczkowe dobrze kontrolowane kwasem walproinowym. Rokowanie i stworzenie planu diagnostycznego u pacjentki z deficytem transportera kreatyny stanowi duże wyzwanie kliniczne z uwagi na niewielką ilość danych literaturowych dotyczących pełnej ekspresji tej mutacji u kobiet. Nowe metody terapeutyczne mogą przynieść obiecującą zmianę dotyczącą prognozy dalszego rozwoju i kontroli napadów u osób z deficytem transportera kreatyny obojga płci.
EN
Cerebral creatine deficiency syndrome is a collective term including different types of disease, all characterised by abnormal creatine level in central nervous system. One of the types, creatine transporter deficiency, is a common cause of X-linked intellectual disability. Typically, it is fully expressed in male patients, however females can also present some symptoms, such as mild intellectual disability, learning difficulties and behavioural problems. The patient presented in this case report is a 4-year-old girl, diagnosed by genetic testing with creatine transporter deficiency showing a novel mutation in SCL6A8 gene, and by proton magnetic resonance spectroscopy in which she presented a typical abnormality in creatine level in central nervous system. The patient presented speech and motor delay, with mild intellectual disability, behavioural problems and seizures well-controlled by valproic acid. The prognosis and therapeutic plan in a female patient with CRTR is a big clinical challenge, as there is few data about this mutation being fully expressed in women. The novel therapy methods may be a promising change in further development and symptoms control in patients with CRTR of both sexes.
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